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| Status |
Public on Feb 19, 2015 |
| Title |
A novel functional role for the serine protease inhibitor SerpinA3N and its substrate leukocyte elastase in neuropathic pain |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Two out-bred rat selection lines were separated to produce different hypersensitivity phenotypes following nerve injury. These lines were termed High Pain and Low Pain (HP or LP). Each sub-strain was either subject to a Sham surgery or a Spinal Nerve Ligation (SNL) surgery to the L4 and L5 spinal nerves. Three days following surgery L4/L5 Dorsal Root Ganglia (DRG) were dissected from these animals. For the rat line separation protocol see: Devor M, Raber P (1990) Heritability of symptoms in an experimental model of neuropathic pain. Pain 42:51-67.
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| Overall design |
12 Hybridizations, 3 per condition; Sham HP DRG; 3 day SNL HP DRG; Sham LP DRG; 3 day SNL LP DRG.
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| Contributor(s) |
Costigan M, Griffin RS |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 19, 2014 |
| Last update date |
Mar 03, 2017 |
| Contact name |
Michael Costigan |
| E-mail(s) |
michael.costigan@childrens.harvard.edu
|
| Phone |
6178402494
|
| Organization name |
Boston Children's Hospital
|
| Department |
Neurology
|
| Lab |
Costigan
|
| Street address |
CLS 12
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL341 |
[RAE230A] Affymetrix Rat Expression 230A Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA267764 |
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