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| Status |
Public on Apr 25, 2016 |
| Title |
The status of lymph node of resectable distant metastaticcolorectal cancer (stage Ⅳ) as a prognostic predictor |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Both the univariate analysis and multivariate analysis showed that the status of primary lymph node was the strongest predict factor. The subgroup analysis confirmed that the lymph node metastasis was associated to worse prognosis only in stage T3 and T4, rather than in stage T1 and T2. We firstly proposed the hypothesis that the status of lymph node reflected delayed diagnose of the disease, rather than the biological behavior of “seed”. The mRNA profile showed that there was minimal difference between lymph node positive and negative subgroups. The status of lymph node reflected delayed diagnose of the disease, rather than the biological behavior of “seed”.
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| Overall design |
15 patients registered in our center with resectable mCRC were selected to extract RNA for further analysis, with 7 patients in lymph node negative subgroup and 8 patients in lymph node positive subgroup. The mRNA profiles of all 15 patients were analyzed by Agilent microarray technology to explore the different expression between lymph node negative subgroup and lymph node positive subgroup.
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| Contributor(s) |
Fu J, Feng L |
| Citation(s) |
26222850 |
| Submission date |
Nov 24, 2014 |
| Last update date |
Apr 23, 2018 |
| Contact name |
jianfie fu |
| E-mail(s) |
nuifu@sina.com
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| Organization name |
The Second Affiliated Hospital of Zhejiang University School of Medicine
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| Department |
Cancer Institute
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| Lab |
Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China
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| Street address |
88 Jiefang Road,
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| City |
Hangzhou |
| ZIP/Postal code |
310009 |
| Country |
China |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA268367 |
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