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Series GSE63876 Query DataSets for GSE63876
Status Public on Dec 05, 2014
Title Gene expression profiles of CD4+CD25+ regulatory T cells during acute and chronic viral infection
Organism Mus musculus
Experiment type Expression profiling by array
Summary Regulatory T (Treg) cells act as terminators in the case of T cell immunity during the acute phase of viral infection. However, their roles in chronic viral infection are not completely understood. We compared the phenotype and function of Treg cells during acute and chronic viral infection using lymphocytic choriomeningitis virus-infected mouse models. Chronic infection, unlike acute infection, led to induction of Treg cells and upregulation of various inhibitory receptors. Treg cells isolated from chronically infected mice (chronic Treg cells) displayed greater suppressive capacity for inhibiting T cell proliferation and subsequent cytokine production than those from naïve (naive Treg cells) or acutely infected mice (acute Treg cells). These gene expression profiles provided evidence that chronic Treg cells display characteristics distinct from either naive or acute Treg cells.
 
Overall design Mouse splenic CD4+CD25+ regulatory T cells were analyzed at 0 day and 16 day after acute or chronic viral infection with LCMV Arm or CL13, respectively.
 
Contributor(s) Park HJ, Park JS, Ha S
Citation(s) 25934860
Submission date Dec 04, 2014
Last update date Aug 06, 2018
Contact name Sang-Jun Ha
E-mail(s) sjha@yonsei.ac.kr
Phone 82-10-5552-7683
Organization name Yonsei University
Department Biochemistry
Lab System Immunology
Street address 50 Yonsei-ro, Science Research Center, Room S423
City Seoul
ZIP/Postal code 120-749
Country South Korea
 
Platforms (1)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
Samples (9)
GSM1558764 Naïve Treg, 0 d, rep1
GSM1558765 Naïve Treg, 0 d, rep2
GSM1558766 Naïve Treg, 0 d, rep3
Relations
BioProject PRJNA269307

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Supplementary file Size Download File type/resource
GSE63876_RAW.tar 20.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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