|
| Status |
Public on Dec 08, 2014 |
| Title |
Core and region enriched networks of behaviorally regulated genes: the singing epigenome |
| Organism |
Taeniopygia guttata |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We queried a songbird brain to discover behaviorally regulated transcriptional mechanisms relevant for speech behavior. About 10% of zebra finch genes showed regulation during singing, and most were brain-region specific. We propose that the brain-regional diversity of the singing-regulated gene networks is derived both from differential combinatorial binding of transcription factors and the epigenetic state of these genes before singing begins. To test this hypothesis, we measured H3K27ac two brain regions that participate in song production.
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| |
|
| Overall design |
The examination of H3K27ac in two brain regions of zebra finch in singing and silent conditions
|
| |
|
| Contributor(s) |
Pfenning AR, Whitney O, Liu F, West AE, Jarvis ED |
| Citation(s) |
25504732 |
| Submission date |
Dec 07, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Andreas R Pfenning |
| E-mail(s) |
apfenning@gmail.com
|
| Organization name |
Massachusetts Institute of Technology
|
| Department |
CSAIL
|
| Lab |
Kellis
|
| Street address |
Computer Science and Artificial Intelligence Laboratory
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19155 |
Illumina HiSeq 2000 (Taeniopygia guttata) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA269549 |
| SRA |
SRP050883 |
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