NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE6399 Query DataSets for GSE6399
Status Public on Dec 02, 2006
Title Comparison between gene expression in heart from Emd KO and control mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary The present research is devoted to the identification of gene(s) severely affected by EMD mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Emd KO mouse model.
Keywords: disease state modification
 
Overall design In the project presented here we performed differential expression in heart from a mouse model of EDMD: a Emd KO mouse created via homologous recombination by Y.Hayashi in Japan (Ozawa, 2006). The emd knock-out mouse showed significantly delayed PR time, that could correspond to impaired atrial-ventricle node conduction. Genes were identified as differentially expressed if they met a false discovery rate threshold of 0.05 in a two-sample t-test (q-value) and showed at least a two-fold difference in expression independent of absolute signal intensity.
 
Contributor(s) Muchir a, Pavlidis p, Hayashi yk, Worman hj
Citation(s) 17567779
Submission date Nov 29, 2006
Last update date Feb 11, 2019
Contact name antoine Muchir
E-mail(s) am2434@columbia.edu
Phone 212 305 4088
Organization name columbia university
Department Medicine
Street address 630W 168th street
City New York
State/province NY
ZIP/Postal code 10032
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (14)
GSM147451 Control male 1
GSM147452 Control male 2
GSM147459 Control male 3
Relations
BioProject PRJNA99709

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6399_RAW.tar 83.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap