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Series GSE64019 Query DataSets for GSE64019
Status Public on Jan 27, 2016
Title Mouse Smarcb1-deficient models recapitulate subtypes of human rhabdoid tumors.
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary Rhabdoid Tumors (RT) are highly aggressive tumors that are frequently localized in the central nervous system (CNS) where they are termed atypical teratoid and rhabdoid tumors (ATRT). We generated conditional Smarcb1-deficient mouse model leads to CNS Smarcb1-deficient tumors.
We used microarrays to compared gene expression profilings of various human and mouse tumors. Our data demonstrate that the Smarcb1-deficient mouse model recapitulates the diversity of human RT.
Overall design [human mRNA] 20 human MRT ( < 5 years), 30 human ATRT ( < 5 years), 4 human MB SHH.
[mouse mRNA] 8 Smarcb1-deficient mouse brain tumors, 15 Smarcb1-deficient T-Cell lymphomas, 3 Mb Shh mouse tumors.
Contributor(s) Bourdeaut F, Richer W, Han Z
Citation(s) 26818002
Submission date Dec 09, 2014
Last update date Mar 26, 2019
Contact name Wilfrid Richer
Organization name Institut Curie
Street address 26 rue d'Ulm
City Paris
ZIP/Postal code 75005
Country France
Platforms (2)
GPL16368 [Mouse4302_Mm_ENTREZG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 16]
GPL17810 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v16]
Samples (80)
GSM1562889 Hs_soft-tissue_MRT (hEC._.INI109)
GSM1562890 Hs_soft-tissue_MRT (hEC._.INI110)
GSM1562891 Hs_soft-tissue_MRT (hEC._.INI116)
BioProject PRJNA269772

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Supplementary file Size Download File type/resource
GSE64019_RAW.tar 388.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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