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| Status |
Public on Jul 01, 2019 |
| Title |
Expression Data for Cisplatin Treated Dorsal Root Ganglia from A/J and C57BL/6J Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Peripheral sensory neuropathy is a common complication to cisplatin treatment in cancer patients. Multiple signaling pathways are likely to be implicated in the pathophysiology, there are no explicit treatments and little is known about predictive factors associated with the onset or progression of cisplatin induced peripheral neuropathy. The transcriptional profiles of differentially senesitive strains of dorsal root ganglion across two inbreed strain of mice will promote better understanding of progression and risk factors assocciated with cisplatin induced peripheral neuropathy. Peripheral neuropathy was induced with a bi-weekly treatment of 4mg/kg cisplatin.
We used microarrays to detail the transciptional profile underlying cisplatin induced peirperal neuropathy in two differentailly sensitve inbreed strains of mice: A/J and C57BL/6J
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| Overall design |
L4-L5 dorsal root ganglia from untreated, vehicle treated and cisplatin treated mice for one and four weeks from A/J and C57BL/6J mice
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| Contributor(s) |
Dorsey SG, Lassiter CB |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 15, 2014 |
| Last update date |
Jul 02, 2019 |
| Contact name |
Susan G Dorsey |
| E-mail(s) |
sdorsey@son.umaryland.edu
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| Phone |
(410) 706-7250
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| Organization name |
University Of Maryland, Baltimore
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| Department |
University of Maryland School of Nursing
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| Lab |
Center for the Advancement of Chronic Pain Research
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| Street address |
655 W. Lombard Street, Room 727A
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21201 |
| Country |
USA |
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| Platforms (1) |
| GPL19559 |
[Mouse4302_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Mouse4302_Mm_ENTREZG_18.0.0] |
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| Samples (47)
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| GSM1565740 |
A/J, four-weeks, navie, biological rep1 |
| GSM1565741 |
A/J, four-weeks, navie, biological rep2 |
| GSM1565742 |
A/J, four-weeks, navie, biological rep3 |
| GSM1565743 |
A/J, four-weeks, vehicle treated, biological rep1 |
| GSM1565744 |
A/J, four-weeks, vehicle treated, biological rep2 |
| GSM1565745 |
A/J, four-weeks, vehicle treated, biological rep3 |
| GSM1565746 |
A/J, four-weeks, cisplatin treated, biological rep1 |
| GSM1565747 |
A/J, four-weeks, cisplatin treated, biological rep2 |
| GSM1565748 |
C57BL/6J, four-weeks, cisplatin treated, biological rep1 |
| GSM1565749 |
C57BL/6J, four-weeks, cisplatin treated, biological rep2 |
| GSM1565750 |
C57BL/6J, four-weeks, cisplatin treated, biological rep3 |
| GSM1565751 |
C57BL/6J, four-weeks, vehicle treated, biological rep1 |
| GSM1565752 |
C57BL/6J, four-weeks, vehicle treated, biological rep2 |
| GSM1565753 |
C57BL/6J, four-weeks, vehicle treated, biological rep3 |
| GSM1565754 |
C57BL/6J, four-weeks, naive, biological rep1 |
| GSM1565755 |
C57BL/6J, four-weeks, naive, biological rep2 |
| GSM1565756 |
C57BL/6J, four-weeks, naive, biological rep3 |
| GSM1565757 |
A/J, one-week, naive, biological rep1 |
| GSM1565758 |
A/J, one-week, naive, biological rep2 |
| GSM1565759 |
A/J, one-week, naive, biological rep3 |
| GSM1565760 |
A/J, one-week, vehicle treated, biological rep1 |
| GSM1565761 |
A/J, one-week, vehicle treated, biological rep2 |
| GSM1565762 |
A/J, one-week, vehicle treated, biological rep3 |
| GSM1565763 |
A/J, one-week, vehicle treated, biological rep4 |
| GSM1565764 |
A/J, one-week, vehicle treated, biological rep5 |
| GSM1565765 |
A/J, one-week, cisplatin treated, biological rep1 |
| GSM1565766 |
A/J, one-week, cisplatin treated, biological rep2 |
| GSM1565767 |
A/J, one-week, cisplatin treated, biological rep3 |
| GSM1565768 |
A/J, one-week, cisplatin treated, biological rep4 |
| GSM1565769 |
A/J, one-week, cisplatin treated, biological rep5 |
| GSM1565770 |
A/J, one-week, cisplatin treated, biological rep6 |
| GSM1565771 |
C57BL/6J, one-week, naive, biological rep1 |
| GSM1565772 |
C57BL/6J, one-week, naive, biological rep2 |
| GSM1565773 |
C57BL/6J, one-week, naive, biological rep3 |
| GSM1565774 |
C57BL/6J, one-week, naive, biological rep4 |
| GSM1565775 |
C57BL/6J, one-week, naive, biological rep5 |
| GSM1565776 |
C57BL/6J, one-week, vehicle treated, biological rep1 |
| GSM1565777 |
C57BL/6J, one-week, vehicle treated, biological rep2 |
| GSM1565778 |
C57BL/6J, one-week, vehicle treated, biological rep3 |
| GSM1565779 |
C57BL/6J, one-week, vehicle treated, biological rep4 |
| GSM1565780 |
C57BL/6J, one-week, vehicle treated, biological rep5 |
| GSM1565781 |
C57BL/6J, one-week, vehicle treated, biological rep6 |
| GSM1565782 |
C57BL/6J, one-week, cisplatin treated, biological rep1 |
| GSM1565783 |
C57BL/6J, one-week, cisplatin treated, biological rep2 |
| GSM1565784 |
C57BL/6J, one-week, cisplatin treated, biological rep3 |
| GSM1565785 |
C57BL/6J, one-week, cisplatin treated, biological rep4 |
| GSM1565786 |
C57BL/6J, one-week, cisplatin treated, biological rep5 |
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| Relations |
| BioProject |
PRJNA270345 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE64174_RAW.tar |
181.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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