|
| Status |
Public on Dec 22, 2015 |
| Title |
Expression data of worms under different caloric restriction mimetic treatments |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
|
| Summary |
We used microarray analysis to further our understanding of the mode of action of the well know caloric restriction mimetic rapamycin and the compound Allantoin first studied in the context of aging in this study. His work helps build on our understanding of potential caloric restriction mimetics predicted from our bioinformatic aproach of quering the Connectivity Map, a database of drug-induced gene expression profiles, using the transcriptional profile of CR to identify drugs that induce a similar or opposite gene expression profile.
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| |
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| Overall design |
Wild type worms of eat-2 mutants (a model of caloric restriction) were treated with the compounds of study with 2% DMSO or DMSO alone to serve as controls. All samples were peformed in triplicate.
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| |
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| Contributor(s) |
Calvert S, Tacutu R, De Magalhaes J |
| Citation(s) |
26676933 |
| Submission date |
Dec 18, 2014 |
| Last update date |
Jul 06, 2016 |
| Contact name |
João Pedro de Magalhães |
| E-mail(s) |
jp@senescence.info
|
| Organization name |
The University of Liverpool
|
| Department |
Institute of Integrative Biology
|
| Street address |
Crown Street,
|
| City |
Liverpool |
| ZIP/Postal code |
L69 7ZB |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL200 |
[Celegans] Affymetrix C. elegans Genome Array |
|
| Samples (15)
|
| GSM1568724 |
Wild type worms treated with 2% DMSO alone replicate 1 |
| GSM1568725 |
Wild type worms treated with 2% DMSO alone replicate 2 |
| GSM1568726 |
Wild type worms treated with 2% DMSO alone replicate 3 |
| GSM1568727 |
Wild type worms treated with rapamycin in 2% DMSO replicate 1 |
| GSM1568728 |
Wild type worms treated with rapamycin in 2% DMSO replicate 2 |
| GSM1568729 |
Wild type worms treated with rapamycin in 2% DMSO replicate 3 |
| GSM1568730 |
Wild type worms treated with allantoin in 2% DMSO replicate 1 |
| GSM1568731 |
Wild type worms treated with allantoin in 2% DMSO replicate 2 |
| GSM1568732 |
Wild type worms treated with allantoin in 2% DMSO replicate 3 |
| GSM1568733 |
Eat-2 mutant worms treated with 2% DMSO alone replicate 1 |
| GSM1568734 |
Eat-2 mutant worms treated with 2% DMSO alone replicate 2 |
| GSM1568735 |
Eat-2 mutant worms treated with 2% DMSO alone replicate 3 |
| GSM1568736 |
Eat-2 mutant worms treated with rapamycin in 2% DMSO replicate 1 |
| GSM1568737 |
Eat-2 mutant worms treated with rapamycin in 2% DMSO replicate 2 |
| GSM1568738 |
Eat-2 mutant worms treated with rapamycin in 2% DMSO replicate 3 |
|
| Relations |
| BioProject |
PRJNA270762 |
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