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| Status |
Public on Jan 31, 2018 |
| Title |
Transcriptome study of colon epithelial cells in Reg3a-transgenic mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The human C-type lectin Reg3a (HIP/PAP) is an antimicrobial peptide that kills Gram-positive bacteria. Reg3a preserves gut microbiota homeostasis, reinforces intestinal barrier function and thereby helps to fight induced colitis in mice.
Transcriptomic data revealed an upregulation of numerous genes involved in the robustness of the intestinal barrier, and the biosynthesis pathway of mucin core 1 and 3 O-glycans.
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| Overall design |
Transcriptome analysis was performed on colon sections from wild-type and Reg3a-transgenic C57BL/6N mice non-treated or treated with 3% dextran sodium sulfate using GeneChip® Mouse Gene 1.0 ST arrays (Affymetrix).
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| Contributor(s) |
Darnaud M, Augui S, Dos Santos A, Desterke C, Braun E, Moniaux N, De Hertogh G, Zheng J, Boisgard R, Neut C, Chiappini F, Guerrieri F, Samuel D, Lepage P, Doré J, Bréchot C, Faivre J |
| Citation(s) |
29133078 |
| Submission date |
Jan 13, 2015 |
| Last update date |
Mar 04, 2019 |
| Contact name |
christophe desterke |
| E-mail(s) |
christophe.desterke@inserm.fr
|
| Phone |
+33 (0)145595316
|
| Organization name |
university Paris Sud11
|
| Department |
UFR medecine institute Andre Lwoff
|
| Lab |
hopital Paul Brousse Batiment Lavoisier
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| Street address |
14-16 avenue Paul Vaillant Couturier
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| City |
VILLEJUIF |
| ZIP/Postal code |
94807 |
| Country |
France |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (35)
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| Relations |
| BioProject |
PRJNA272541 |
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