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| Status |
Public on Feb 19, 2018 |
| Title |
Gene expression in diabetes-prone (NZO/HiBomDife) and diabetes-resistant (C57BL/6.V-Lepob/ob) mouse strains |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Mouse strains like NZO and B6-ob/ob differ in their susceptibility to diet-induced diabetes. Comparison of the islet transcriptomes leads to genes that are either involved in protection or apoptosis of pancreatic islet cells upon carbohydrate challenge.
Genes being upregulated in NZO can be seen as drivers of beta cell failure, while genes upregulated in B6-ob/ob are most likely involved in beta cell protection.
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| Overall design |
Male NZO and B6-ob/ob mice were kept on a carbohydrate-free high-fat diet until the age of 18 wks. Afterwards, diet was switched to a carbohydrate-containing diet to induce glucolipotoxic stress. After 48 h pancreatic islets were isolated for transcriptome analysis.
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| Contributor(s) |
Kluth O, Schürmann A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 14, 2015 |
| Last update date |
Feb 20, 2018 |
| Contact name |
Annette Schürmann |
| E-mail(s) |
schuermann@dife.de
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| Organization name |
German Institute of Human Nutrition Potsdam-Rehbruecke
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| Department |
Department of Experimental Diabetology
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| Street address |
Arthur-Scheunert-Allee 114-116
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| City |
Nuthetal |
| State/province |
BRB |
| ZIP/Postal code |
14558 |
| Country |
Germany |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA272583 |
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