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Status |
Public on Nov 14, 2016 |
Title |
Bach2 inhibits Th2-type immune responses by regulating glutamine metabolism [expression array] |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
It is becoming clear that the acquisition of T cell functions is closely linked to the reprogramming of the metabolic pathway. However, the impact of metabolic changes on the differentiation of helper T cell subsets remains unclear. We herein demonstrate a critical role of glutamine metabolism in regulating type 2-immune response. Bach2, a transcriptional repressor, binds to an AP-1 motif, and suppresses Th2 cell differentiation and glutaminolysis. Glutaminase 2, which controls glutamine metabolism, was identified as a Bach2 target gene. The pharmacological inhibition of glutamine metabolism normalized allergic lung inflammation that developed spontaneously in T-cell specific Bach2-deficient mice. These findings reveal the importance of the Bach2-dependent modulation of glutamine metabolism in regulating Th2 cell differentiation and Th2 cell- mediated inflammation.
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Overall design |
Gene expression in Bach2 WT-Th (Bach2 WT-Th (-)), Bach2 KO-Th (Bach2 KO-Th (-)), restimulated Bach2 WT-Th (Bach2 WT Th (+)) and re-stimulated Bach2 KO-Th (Bach2 KO Th (+)).
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Contributor(s) |
Kuwahara M, Izumoto M, Suzuki J, Ochi M, Shioiri K, Matsumoto A, Yamada T, Shinoda K, Nakayama T, Kurosaki T, Sawazaki T, Ohara O, Yasukawa M, Yamashita M |
Citation(s) |
27581382 |
Submission date |
Jan 19, 2015 |
Last update date |
Jan 12, 2017 |
Contact name |
Makoto Kuwahara |
E-mail(s) |
mkuwa@m.ehime-u.ac.jp
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Organization name |
Graduate School of Medicine, Ehime University
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Department |
Department of Immunology
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Lab |
Immunology
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Street address |
Shitsukawa
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City |
Toon-shi |
State/province |
Ehime |
ZIP/Postal code |
791-0295 |
Country |
Japan |
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Platforms (1) |
GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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Samples (4)
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This SubSeries is part of SuperSeries: |
GSE65084 |
Bach2-Batf interactions control Th2-type immune responses by regulating the IL-4 amplification loop |
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Relations |
BioProject |
PRJNA272912 |
Supplementary file |
Size |
Download |
File type/resource |
GSE65083_RAW.tar |
8.7 Mb |
(http)(custom) |
TAR (of TXT) |
Processed data included within Sample table |
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