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Series GSE65346 Query DataSets for GSE65346
Status Public on Jun 01, 2015
Title Liver gene expression response to circadian rhythm disruption
Organism Mus musculus
Experiment type Expression profiling by array
Summary Frequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the presence of circadian rhythm disturbance (CRD) require 24-hr (around the clock) measurements, which is not practical for use in large-scale (human) studies. The aim of the present study was to identify universal biomarkers for CRD independent of time of day using a transcriptomics approach. Female FVB mice were exposed to six shifts in a clockwise (CW) and counterclockwise (CCW) CRD protocol and sacrificed at baseline and after 1 shift, 6 shifts, 5 days recovery and 14 days recovery, respectively. At six time-points during the day, livers were collected for mRNA microarray analysis. Bioinformatics analysis identified a set of universal markers for CRD. These biomarkers might be useful to measure CRD and can be used later on for monitoring the effectiveness of intervention strategies aiming to prevent or minimize chronic adverse health effects.
 
Overall design 120 samples, 2 or 4 replicates per group
 
Contributor(s) Pennings J, Rodenburg W
Citation(s) 25984797
Submission date Jan 27, 2015
Last update date Jun 02, 2015
Contact name Jeroen Pennings
E-mail(s) Jeroen.Pennings@rivm.nl
Phone +31 88 689 2214
Organization name Natl. Inst. Public Health & Environment
Street address A. van Leeuwenhoeklaan 9
City Bilthoven
ZIP/Postal code 3721MA
Country Netherlands
 
Platforms (1)
GPL10192 NimbleGen Mus musculus MM9 Expression Array (12x135k)
Samples (120)
GSM1592881 Control_no shift_0h_nr100
GSM1592882 Control_no shift_0h_nr97
GSM1592883 Control_no shift_0h_nr98
Relations
BioProject PRJNA273743

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE65346_RAW.tar 488.1 Mb (http)(custom) TAR (of FTR)
Processed data included within Sample table
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