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Series GSE6540 Query DataSets for GSE6540
Status Public on Dec 14, 2007
Title Expression data from olfactory epithelium of Lip-C-treated mice compared to Lip-O-treated control mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Microarray analysis of gene expression in the olfactory epithelium of macrophage depleted mice to study the role of macrophages in regulating neurodegeneration, neuroprotection, and neurogenesis of olfactory sensory neurons
Keywords: comparison of gene expression level in sham and 48 hr OBX Lip-O mice versus Lip-C mice
 
Overall design Olfactory epithelium from LIp-C-treated and Lip-O-treated mice was microdissected for RNA extraction and hybridization on Affymetrix microarrays. We compared levels of gene expression in macrophage-depleted and non-depleted sham and 48 hr OBX mice using a 2x2 ANOVA and pairwise comparisons to identify molecular mechanisms of macrophage-mediated neurodegeneration, neuroprotection, and neurogenesis and to validate the gene expression patterns using real-time RT-PCR and immunohistochemistry
 
Contributor(s) Borders AS, Hersh MA, Getchell ML, vanRooijen N, Cohen DA, Stromberg AJ, Getchell TV
Citation(s) 17848607
Submission date Dec 15, 2006
Last update date Feb 11, 2019
Contact name Marilyn L. Getchell
E-mail(s) mgetch@uky.edu
Organization name University of Kentucky
Department Anatomy and Neurobiology
Lab Sanders-Brown Center on Aging
Street address 800 South Limestone St.
City Lexington
State/province KY
ZIP/Postal code 40536-0230
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM151586 Lip-C-treated 48 hr OBX C57 mouse, biol rep1
GSM151587 Lip-C-treated 48 hr OBX C57 mouse, biol rep2
GSM151588 Lip-C-treated 48 hr OBX C57 mouse, biol rep3
Relations
BioProject PRJNA98581

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6540_RAW.tar 47.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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