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Series GSE6581 Query DataSets for GSE6581
Status Public on Dec 20, 2006
Title Expression data from mammary glands of transgenic mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary The aim of our work was the comparison of human and mouse gene expression data and to identify a conserved breast tumor gene set. The results encourage the usefulness of transgenic mice as a model for human breast cancer formation and therapy.
Keywords: Comparison
 
Overall design The aim of our work was to establish a database for breast cancer gene expression data in order to compare human and mouse breast cancer. We identified human and mouse homologues genes and compared the expression profile of 24 human breast tumors with six WAP-SVT/t breast tumors (WAP-SVT/t animals, line 8). Our studies confirmed the heterogeneity in gene expression of human as well as mouse breast cancer cells. However, 63 genes were found to be differentially expressed (upregulated: 40; downregulated: 23 genes) in at least 75% of the breast tumors of both species.
Web link http://www.charite.de/molbiol/bioinf/tumbiol/
 
Contributor(s) Klein A
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Dec 20, 2006
Last update date May 04, 2018
Contact name Andreas Klein
E-mail(s) andreas.klein@charite.de
Phone +49 30 450 528087
Fax +49 30 450 52945
URL http://www.charite.de/molbiol/bioinf/tumbiol/
Organization name Charité (CCO)
Department Institute of Biochemistry
Street address Charitéplatz 1
City Berlin
ZIP/Postal code 10117
Country Germany
 
Platforms (1)
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (3)
GSM152127 585pos3 tumor
GSM152128 585pos5 tumor
GSM152129 597pos9 tumor
This SubSeries is part of SuperSeries:
GSE6772 Comparison of gene expression data from human and mouse breast cancers
Relations
BioProject PRJNA104239

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6581_RAW.tar 7.4 Mb (http)(custom) TAR (of CEL)

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