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| Status |
Public on Feb 13, 2015 |
| Title |
Effects of polyamidoamine dendrimer on neuronal differentiation from human neural progenitor cells using the neurosphere assay |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Polyamidoamine (PAMAM) dendrimers have been investigated for the development of engineered nanomaterial drug delivery systems and other industrial uses. However, the major concern for their potential adverse effects on human neural progenitor cells remains unclear. In the present study, we employed human neural progenitor cells (hNPCs) to study the effects of G4-PAMAM dendrimers on neuronal differentiation.
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| Overall design |
Neurospheres were treated with PAMAM dendrimer-NH2 (10 μg/mL) for 72 h. Four neurospheres from the treatment and control groups were pooled together, and RNAs were isolated from each group.
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| Citation(s) |
27125967 |
| Submission date |
Feb 12, 2015 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Yang Zeng |
| E-mail(s) |
zeng.yang@nies.go.jp
|
| Phone |
0298502464
|
| Organization name |
NIES
|
| Street address |
Onogawa 16-2
|
| City |
tsukuba |
| State/province |
ibaraki |
| ZIP/Postal code |
305-8506 |
| Country |
Japan |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA275274 |
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