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| Status |
Public on Jun 30, 2016 |
| Title |
Transcriptomic analysis of two human non-small-cell lung cancer cell lines in response to SN1 methylating-agents treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Methylating agents of SN1 type constitute a widely used class of anticancer drugs, the effect of which on human non-small-cell lung cancer (NSCLC) has not been adequately studied. We thus studied the effect of N-methyl-N-nitrosourea (MNU), a model SN1 methylating agent, on two human NSCLC cell lines: A549 (p53wt) and H157 (p53null). We investigated the mechanism of MNU-induced cell death through a time course gene expression profiling study, 24, 48 and 72h following treatment.
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| Overall design |
Two human NSCLC cell lines (A549, H157) were treated with MNU or DMSO for 24h, 48h, or 72h. 34 total samples were analyzed.
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| Contributor(s) |
Papadodima O, Moulos P, Koryllou A, Kolisis F, Chatziioannou A, Pletsa V |
| Citation(s) |
27467507 |
| Submission date |
Feb 13, 2015 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Olga Papadodima |
| E-mail(s) |
opapadod@eie.gr
|
| Phone |
++2107273721
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| Organization name |
National Hellenic Research Foundation
|
| Street address |
48, Vasileos Konstantinou av.
|
| City |
Athens |
| ZIP/Postal code |
11635 |
| Country |
Greece |
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| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
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| Samples (34)
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| Relations |
| BioProject |
PRJNA275433 |
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