|
Status |
Public on Jul 01, 2015 |
Title |
Expression data of embryonic kidney from MWF E15.5 and SHR 16.0 rats |
Organism |
Rattus norvegicus |
Experiment type |
Expression profiling by array
|
Summary |
Defects in nephrogenesis can have detrimental effects on cardiovascular and renal health in adult life. This is confirmed by observations in the Munich Wistar Frömter (MWF) rat that exhibits a congenital nephron deficit and renal failure with age. We performed genome-wide transcriptome analysis in embryonic kidneys to identify candidate genes for the reduced nephron number in MWF. We compared MWF E15.5 with stage-matched spontaneously hypertensive rats (SHR) at E16. Microarray analysis revealed 311 transcripts representing 253 known genes with differential expression between MWF and SHR (FC >+1.5 or <-1.5, FDR<0.05).
|
|
|
Overall design |
8 samples were analyzed, n=4 per group
|
|
|
Contributor(s) |
Kreutz R |
Citation missing |
Has this study been published? Please login to update or notify GEO. |
Submission date |
Feb 19, 2015 |
Last update date |
Jul 01, 2015 |
Contact name |
Reinhold Kreutz |
Organization name |
Charité
|
Street address |
Charitéplatz 1
|
City |
Berlin |
ZIP/Postal code |
10117 |
Country |
Germany |
|
|
Platforms (2) |
GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
GPL10741 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [probe set (exon) version] |
|
Samples (16)
|
|
Relations |
BioProject |
PRJNA275838 |