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| Status |
Public on Sep 17, 2015 |
| Title |
Frequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia (mouse) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Murine CD45.1+ CD117+ BM cells were co-transduced pairwise with retroviral vectors expressing Hoxa9, Meis1, Foxc1 or a control empty vector. Ninety-six hours later 10^6 drug resistant cells were transplanted into CD45.2+ irradiated congenic recipients. To investigate the consequences of FOXC1 expression on the transcriptome in murine AML, we performed exon array analysis using flow sorted CD117+Gr1+ leukemia cells recovered from sick mice (Hoxa9/control; Moxa9/Meis1; or Hoxa9/FOXC1 leukemias; 3 mice per cohort).
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| Overall design |
Nine exon arrays total; 3 arrays for each cohort (Hoxa9/control; Moxa9/Meis1; or Hoxa9/FOXC1), each from a separate mouse.
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| |
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| Contributor(s) |
Somervaille T |
| Citation(s) |
26373280 |
| Submission date |
Feb 24, 2015 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Tim C Somervaille |
| E-mail(s) |
tim.somervaille@cruk.manchester.ac.uk
|
| Organization name |
Cancer Research UK Manchester Institute
|
| Lab |
Leukaemia Biology Laboratory
|
| Street address |
Wilmslow Road
|
| City |
Manchester |
| State/province |
Lancashire |
| ZIP/Postal code |
M20 4BX |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE66256 |
Frequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia |
|
| Relations |
| BioProject |
PRJNA276270 |
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