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Series GSE6681 Query DataSets for GSE6681
Status Public on Jan 25, 2007
Title Foxp3 ablation in peripheral mature regulatory T cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3.
Keywords: genetic modification
 
Overall design Compare Cre recombinase treated peripheral regulatory T cells possessing a Cre sensitive Foxp3 locus to Cre treated regulatory T cells with a wild type Foxp3 locus. Cre exposure is observed via the Cre sensitive expression of the yellow flourescent protein molecule.
 
Contributor(s) Williams LM, Rudensky AY
Citation(s) 17220892
Submission date Jan 08, 2007
Last update date Feb 11, 2019
Contact name Alexander Rudensky
Organization name University of Washington
Department Immunology
Street address 1959 Pacific St
City Seattle
State/province WA
ZIP/Postal code 98195
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (4)
GSM154366 YFP+Foxp3delta r1
GSM154369 YFP+Foxp3+ r1
GSM154371 YFP+Foxp3delta r2
Relations
BioProject PRJNA99057

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6681_RAW.tar 13.0 Mb (http)(custom) TAR (of CEL)
Raw data not provided for this record
Raw data provided as supplementary file

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