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| Status |
Public on Aug 06, 2015 |
| Title |
Toxicogenomic Screen of Replacements for bis(2-ethylhexyl) phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Phthalate plasticizers are being phased out of consumer products because of their endocrine disrupting properties. This has resulted in a need to find safe alternatives that can plasticize polyvinyl chloride (PVC) while being inexpensive and biodegradable. We aim to study the toxicogenomic profile of mono-(2-ethylhexyl) phthalate (MEHP, the active metabolite of bis(2-ethylhexyl) phthalate, DEHP), the commercial plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), and three plasticizers in development (1,4 butanediol dibenzoate (BDB), dioctyl succinate (DOS), and dioctyl maleate (DOM)) using the immortalized TM4 Sertoli cell line.
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| Overall design |
Each sample contains four biological replicates except for DOS that contains three. The control is 1.0% DMSO as this was the vehicle used to solubilize the test compounds.
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| Contributor(s) |
Nardelli TC, Robaire B |
| Citation(s) |
26445464 |
| Submission date |
Mar 12, 2015 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Thomas Constantine Nardelli |
| E-mail(s) |
thomas.nardelli@mail.mcgill.ca
|
| Phone |
514-398-6241
|
| Organization name |
McGill University
|
| Department |
Pharmacology and Therapeutics
|
| Lab |
Bernard Robaire
|
| Street address |
3655 Prom. Sir-William-Osler
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3G 1Y6 |
| Country |
Canada |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA278011 |
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