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Series GSE6765 Query DataSets for GSE6765
Status Public on Jan 20, 2007
Title Aeromonas caviae infection, 24 hours
Organism Mus musculus
Experiment type Expression profiling by array
Summary Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus. Microarray profiling of murine small intestinal extracts, 24 hours after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (γ-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF-α) transcripts. A. caviae has always been considered an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests A. caviae colonizes murine intestinal tract and causes what has been described by others as a dysregulatory cytokine response leading to an irritable bowel-like syndrome. This response would explain why a number of diarrheal waterborne outbreaks have been attributed to A. caviae even though it lacks obvious enteropathogenic properties.
Keywords: Aeromonas caviae, infection, disease mechanism, TH1 resposne
Overall design Biological replicates (n=5), controls are uninfected mice, test replicates are infected with organism
Contributor(s) Vesper S, Rodgers M, Lye D, Stelma G, Donohue M
Citation(s) 20130691
Submission date Jan 17, 2007
Last update date Feb 11, 2019
Contact name Samuel Hayes
Phone 513-569-7514
Organization name United States Environmental Protection Agency
Department MS-387
Street address 26 W. Martin Luther King Dr.
City Cincinnati
State/province OH
ZIP/Postal code 45268
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (9)
GSM155916 NRMRL test replicate01, EPA72 batch052005 430_2 chip
GSM155917 NRMRL test replicate02, EPA72 batch052005 430_2 chip
GSM155918 NRMRL test replicate03, EPA72, batch052005 430_2 chip
BioProject PRJNA98937

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6765_RAW.tar 36.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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