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| Status |
Public on Apr 09, 2015 |
| Title |
Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To identify potential candidate genes for future pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we used gene expression arrays to analyze changes induced by risperidone in mice strains with different susceptibility to EPS
This study is a part of a convergent functional genomic approach that plans to integrate the data presented here with: data from gene expression analysis of neuroblastoma cell line under treatment with risperidone; and data from gene expression analysis of peripheral blood from first psychotic patients treated with risperidone.
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| Overall design |
Gene expression was assessed by microarray (Affymetrix GeneChip® Arrays MG 430 PM) in mice treated with risperidone 1mg/kg for three consecutive days
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| Contributor(s) |
Mas S, Gassò P, Lafuente A |
| Citation(s) |
26122020 |
| Submission date |
Apr 09, 2015 |
| Last update date |
Aug 06, 2018 |
| Contact name |
Sergi Mas Herrero |
| E-mail(s) |
sergimash@ub.edu
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| Phone |
+34 934024526
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| Organization name |
University of Barcelona
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| Department |
Pharmacology, School of Medicine
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| Street address |
Casanova 143
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| City |
Barcelona |
| State/province |
Catalunya |
| ZIP/Postal code |
08030 |
| Country |
Spain |
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| Platforms (1) |
| GPL11180 |
[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate |
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| Samples (16)
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| GSM1654821 |
untreated A/J mice, biological rep 4 |
| GSM1654822 |
treated A/J mice, biological rep 1 |
| GSM1654823 |
treated A/J mice, biological rep 2 |
| GSM1654824 |
treated A/J mice, biological rep 3 |
| GSM1654825 |
treated A/J mice, biological rep 4 |
| GSM1654826 |
untreated DBA2J mice, biological rep 1 |
| GSM1654827 |
untreated DBA2J mice, biological rep 2 |
| GSM1654828 |
untreated DBA2J mice, biological rep 3 |
| GSM1654829 |
untreated DBA2J mice, biological rep 4 |
| GSM1654830 |
treated DBA2J mice, biological rep 1 |
| GSM1654831 |
treated DBA2J mice, biological rep 2 |
| GSM1654832 |
treated DBA2J mice, biological rep 3 |
| GSM1654833 |
treated DBA2J mice, biological rep 4 |
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| Relations |
| BioProject |
PRJNA280755 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE67723_RAW.tar |
34.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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