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| Status |
Public on May 05, 2016 |
| Title |
Disruption of Na+/H+ exchanger regulatory factor 2 scaffold suppresses colon cancer proliferation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
A key function of Na+/H+ exchanger regulatory factor 2 (NHERF2) is spatial organization of signaling proteins to facilitate signal transduction. The role of NHERF2 in cancer progress is not well understood. This study determines how loss of NHERF2 alter colon cancer progress.
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| Overall design |
We show that loss of NHERF2 decreases colon cancer cell proliferation. To compare the effects of NHERF2 and LPA2 at the molecular level, HCT116 colon cancer xenograft with knockdown of NHERF2 or LPA2 was analyzed by RNAseq.
Please note that standard cufflinks/cuffdiff output files are provided in the compressed tar files as processed data and Cufflinks/Cuffdiff output file content/formats are described at:
https://cole-trapnell-lab.github.io/cufflinks/cuffdiff/#cuffdiff-output-files
https://cole-trapnell-lab.github.io/cufflinks/file_formats/
(also included in the 'readme.txt' file)
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| Contributor(s) |
Yun C |
| Citation(s) |
26867566 |
| Submission date |
Apr 15, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Viren Patel |
| Organization name |
Emory University School of Medicine
|
| Department |
EICC
|
| Street address |
101 Woodruff Circle
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30322 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA281231 |
| SRA |
SRP057199 |
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