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| Status |
Public on Aug 12, 2015 |
| Title |
In vitro activation and reversion of human primary hepatic stellate cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Liver fibrosis is characterized by the excessive formation and accumulation of matrix proteins as a result of wound healing in the liver. A main event during fibrogenesis is the activation of the liver resident quiescent hepatic stellate cell (qHSC). Recent studies suggest that reversion of the activated HSC (aHSC) phenotype into a quiescent-like phenotype could be a major cellular mechanism underlying fibrosis regression in the liver, thereby offering new therapeutic perspectives for the treatment of liver fibrosis. The goal of the present study is to identify experimental conditions that can revert the activated status of human HSCs and to map the molecular events associated with this phenotype reversion by gene expression profiling
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| Overall design |
Transcriptomic profiling of primary human quiescent HSCs (qHSCs), in vitro activated HSCs (aHSCs) and in vitro reverted HSCs (rHSCs). The cell types come from different donors (This is detailed in the original manuscript.).
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| Contributor(s) |
El Taghdouini A, Najimi M, Sancho-Bru P, Sokal E, van Grunsven LA |
| Citation(s) |
26251672 |
| Submission date |
Apr 17, 2015 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Adil El Taghdouini |
| E-mail(s) |
aeltaghd@vub.ac.be
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| Phone |
+3224774259
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| Organization name |
Vrije Universiteit Brussel
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| Department |
Cell Biology
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| Lab |
Liver Cell Biology
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| Street address |
Laarbeeklaan, 103
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| City |
Brussels |
| ZIP/Postal code |
1090 |
| Country |
Belgium |
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| Platforms (1) |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA282909 |
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