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| Status |
Public on Feb 09, 2018 |
| Title |
PRC2 mediates paternal epigenetic inheritance: comparison of heterozygous mutant embryos |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Determining the mechanisms that establish and regulate the transmission of non-genetic (i.e. epigenetic) information from parent to offspring is critical for understanding disease heredity. Using an innovative model to assess transmission of epigenetic effects, we provide evidence that Polycomb Repressive Complex 2 (PRC2) mediates inheritance through the male germline. This study reveals a novel role for histone modifying complexes in epigenetic inheritance, with important implications for understanding disease inheritance.
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| |
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| Overall design |
Comparison of gene expression in E8.5 embryos with the same heterozygous genotype, produced from heterozygous (n=4) and homozygous (n=4) Eedl7Rn5-1989SB fathers reveal differences in gene expression possibly due to altered epigenetic patterning in the sperm.
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| |
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| Contributor(s) |
Stringer JM, Forster SC, Western PS |
| Citation(s) |
30236109 |
| Submission date |
Apr 23, 2015 |
| Last update date |
May 17, 2019 |
| Contact name |
Sam Forster |
| Organization name |
Monash University
|
| Department |
Monash Institute
|
| Lab |
Centre for Innate Immunity and Infectious Diseases
|
| Street address |
27 - 31 Wright Street
|
| City |
Clayton |
| State/province |
Victoria |
| ZIP/Postal code |
3168 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
|
| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE68213 |
PRC2 mediates paternal epigenetic inheritance |
|
| Relations |
| BioProject |
PRJNA282098 |
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