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Series GSE6857 Query DataSets for GSE6857
Status Public on Jan 14, 2008
Title Unique MicroRNA Expression Signature Predicts Survival, Metastases and Recurrence of HCC
Platform organisms Homo sapiens; Mus musculus
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary In this study we investigated the miRNA expression profile of Hepatocellular carcinoma (HCC) specimens from radical resection. We developed a unique 20 miRNA signature that could significantly distinguish HCC venous metastasis from metastasis-free HCC. In contrast to HCC staging systems, this signature was capable of predicting survival and recurrence of HCC patients with multinodular or solitary tumors, including those with early-stage disease. Moreover, the signature was an independent and significant predictor of patient prognosis and relapse when compared to other available clinical parameters. Our study suggests that these 20 miRNAs can enable HCC prognosis and may have clinical utility for the advance identification of HCC patients with a propensity towards metastasis/recurrence.
Keywords: disease state design
 
Overall design Gene expression profiles were conducted in primary HCC and corresponding noncancerous hepatic tissues from 244 Chinese HCC patients. A total of 134 well-defined cases were used as a training group. Among them, 30 had primary HCC lesions accompanied by tumor emboli and 104 had solitary HCC with no metastasis/recurrence found at follow-up (3 yr). We used a testing group of 110 independent cases. The testing cases included 43 multinodular and 67 solitary HCC. In addition, eight normal liver tissues from disease-free patients were included as normal controls. In the analysis of the 244 HCC cases, RNA was isolated in a pairwise fashion from tumor or non-tumor tissue and samples were selected in random order for miRNA analysis to avoid grouping bias.
 
Citation(s) 18176954, 23376425, 29209147
Submission date Jan 24, 2007
Last update date Oct 04, 2019
Contact name Xin Wei Wang
E-mail(s) xw3u@nih.gov
Phone 240-760-6858
Organization name National Cancer Institute
Department Laboratory of Human Carcinogenesis
Lab Liver Carcinogenesis Unit
Street address 37 Convent Drive
City Bethesda
State/province MD
ZIP/Postal code 20892-4255
Country USA
 
Platforms (1)
GPL4700 OSU-CCC MicroRNA Microarray Version 2.0
Samples (482)
GSM157887 Hepatocellular carcinoma (HCC), metastasis free, 148A
GSM157888 Hepatocellular carcinoma (HCC), venous metastasis, 272A
GSM157889 Hepatocellular carcinoma (HCC), metastasis free, 268A
Relations
BioProject PRJNA99101

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6857_RAW.tar 211.5 Mb (http)(custom) TAR (of GPR, TXT)
GSE6857_normalized_data_482_arrays.xls.gz 4.6 Mb (ftp)(http) XLS
Processed data included within Sample table
Processed data are available on Series record
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