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| Status |
Public on Aug 29, 2017 |
| Title |
An Nfic-Hedgehog Signaling Cascade Regulates Tooth Root Development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study aimed to perform transcriptome profiling of Nfic-/- and corresponding control tooth germ at root initiation stage to identify differentially expressed for key regulators of root development.
Coordination between the Hertwig’s Epithelial Root Sheath (HERS) and apical papilla (AP) is crucial for proper root development process. The Hedgehog (Hh) signaling pathway and Nfic are both involved in tooth root development.
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| Overall design |
mRNA profiling of apical half of tooth germ from 6 pairs of 4-day-old Nfic-/- and littermate Nfic+/- control mice were generated using Illumina Next-Seq 500
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| Contributor(s) |
Liu Y, Feng J, Li J, Zhao H, Liu Y, Ho T, Chai Y |
| Citation(s) |
26293299 |
| Submission date |
May 19, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Vasu Punj |
| E-mail(s) |
vasupunj@gmail.com
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| Organization name |
USC
|
| Street address |
Biggy Street
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90033 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA284406 |
| SRA |
SRP058506 |
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