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Series GSE69078 Query DataSets for GSE69078
Status Public on Jul 09, 2015
Title Comparison of the gene expression profiles of carfilzomib-resistant derivatives versus parental human myeloma cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary KMS-11 and KMS-34 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. The resulting cell cultures, denoted KMS-11/Cfz and KMS-34/Cfz, respectively, retained resistance to carfilzomib even when tested after removal of selective pressure for approximately 8 weeks.
Overall design KMS-11/Cfz and KMS-34/Cfz cells were profiled for gene expression after 1 week of growth in the absence of carfilzomib together with parental KMS-11 and KMS-34 cells which had not been selected in the drug (triplicate samples).
Contributor(s) Riz I, Hawley TS, Hawley RG
Citation(s) 26109433
Submission date May 20, 2015
Last update date Mar 25, 2019
Contact name Robert Hawley
Organization name George Washington University
Department Anatomy and Regenerative Biology
Street address 2300 I Street NW, Suite 431
City Washington
State/province DC
ZIP/Postal code 20037
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (12)
GSM1692587 KMS-11/Cfz_rep1_261900
GSM1692588 KMS-11/Cfz_rep2_261899
GSM1692589 KMS-11/Cfz_rep3_261901
BioProject PRJNA284490

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69078_RAW.tar 60.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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