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Status |
Public on Feb 22, 2007 |
Title |
The Retinoblastoma Binding Protein RBP2 is an H3K4 demethylase |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
The roles of histone demethylase RBP2 in gene expression were assessed using gene expression profiling experiments with wild type and RBP2-/- primary MEFs. Several cytokine genes including SDF1 and Kit ligand were upregulated upon inactivation of RBP2. Keywords: mouse embryonic fibroblasts, gene expression profiling, microarray, Affymetrix Mouse Genome 430 2.0, cell type comparison
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Overall design |
Total RNA were extracted from two independent lines of wild type and RBP2 primary MEFs at passage 3 and analyzed for gene expression profiles using Affymetrix platform.
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Contributor(s) |
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG |
Citation(s) |
17320163 |
Submission date |
Feb 02, 2007 |
Last update date |
Feb 11, 2019 |
Contact name |
Qin Yan |
E-mail(s) |
qin.yan@yale.edu
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Phone |
2037856672
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Organization name |
Yale School of Medicine
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Street address |
Department of Pathology, PO Box 208023
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City |
New Haven |
State/province |
CT |
ZIP/Postal code |
06520 |
Country |
USA |
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Platforms (1) |
GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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Samples (4)
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Relations |
BioProject |
PRJNA99331 |