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Series GSE6968 Query DataSets for GSE6968
Status Public on Apr 27, 2007
Title Spermatozoal RNA Profiles (HumanRef-8 BeadChip)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Normal human spermatogenesis concludes with the formation of large numbers of morphologically well developed spermatozoa. While transcriptionally quiescent these cells carry an RNA payload that reflects the final spermiogenic phase of transcription. We report here the spermatozoal transcript profiles characteristic of normally fertile individuals and infertile males suffering from a consistent and severe teratozoospermia in which under 4% of spermatozoa are morphologically normal. RNA was extracted from the purified sperm cells of ejaculate and hybridized to Illumina WG ref8 Microarrays.
Keywords: disease state analysis
Overall design Spermatozoal RNAs were prepared from the semen samples of 10 individuals. An asymmetric dual block design was adopted with biological replicates in both blocks. 4 semen samples were assessed from normally fertile males. 6 semen samples were assessed from infertile individuals with a severe and consistent teratozoospermia (predominantly DFS).
Web link
Contributor(s) Platts AE, Dix DJ, Chemes HE, Thompson KE, Goodrich R, Rockett JC, Rawe VY, Quintana S, Diamond MP, Strader LF, Krawetz SA
Citation(s) 17327269
Submission date Feb 06, 2007
Last update date Mar 17, 2012
Contact name Stephen A Krawetz
Organization name Wayne State University
Street address 275 East Hancock, CS Mott Center
City Detroit
State/province MI
ZIP/Postal code 48207
Country USA
Platforms (1)
GPL2700 Sentrix HumanRef-8 Expression BeadChip
Samples (10)
GSM160635 Teratozoospermic individual: Sample 23A
GSM160636 Teratozoospermic individual: Sample 23B
GSM160637 Teratozoospermic individual: Sample 23C
This SubSeries is part of SuperSeries:
GSE6969 Spermatozoal RNA Profiles from Normally Fertile and Heterogeneously Teratozoospermic Subjects
BioProject PRJNA104125

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6968_RAW.tar 2.9 Mb (http)(custom) TAR (of TXT)

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