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| Status |
Public on Sep 20, 2015 |
| Title |
Catalytically inactive Ring1B maintains near wildtype levels of gene expression in mESCs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
This experiment was designed to determine the extent of gene misregulation in mESCs containing catalytically dead Ring1B in comparison to mESCs lacking Ring1B.
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| Overall design |
Polyadenylated mRNA was prepared from wildtype mESCs (WT), mESCs deficient for Ring1B (KO) and mESCs cells containing catalytically dead Ring1B (I53A). Each sample is represented by 3 biological replicate hybridisations.
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| |
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| Contributor(s) |
Moffat M, Illingworth RS, Wilson A, Read D, Marulasiddappa PM, Adams I, Bickmore WA |
| Citation(s) |
26385961 |
| Submission date |
Jun 12, 2015 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Rob S Illingworth |
| E-mail(s) |
robert.illingworth@ed.ac.uk
|
| Phone |
01316519640
|
| Organization name |
The University of Edinburgh
|
| Department |
Centre for regenerative Medicine
|
| Lab |
Illingworth
|
| Street address |
Centre for Regenerative Medicine
|
| City |
Edinburgh |
| State/province |
Midlothian |
| ZIP/Postal code |
EH16 4UU |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE69978 |
Loss of Ring1B catalytic activity causes a pronounced reduction in H3K27me3 deposition yet minimally disrupts the expression of target genes |
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| Relations |
| BioProject |
PRJNA286873 |
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