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Series GSE7006 Query DataSets for GSE7006
Status Public on May 12, 2010
Title Comparison of infrarenal and suprarenal sections of mouse ApoE-/- abdominal aorta
Organism Mus musculus
Experiment type Expression profiling by array
Summary The ApoE -/- mice model of abdominal aortic aneurysm (AAA) involves introducing Angiotensin II subcutaneously to 14 week old male mice for 4 weeks by osmotic pump. A significant number of mice will develop aneurysm-like dilations in the suprarenal section of the abdominal aorta (SRA) that have a number of similarities to the human condition and make this a useful model of AAA. The mouse infrarenal aorta is very resistant to aneurysm formation while in humans AAA predominately occurs in the infrarenal section of the aorta (IRA).
There have been a number of theories proposed to explain the site selctivity of aneurysm formation in AAA and this mice model. This study was designed to ascertain differences between SRA and IRA that may explain this site selectivity.
Keywords: tissue type comparison
 
Overall design The aortas of five groups of 2 male (14 weeks old) ApoE-/- mice were harvested and divided into infrarenal and suprarenal sections. RNA and proteins were extracted from each group of pooled segments to allow comparison between individual gene expression levels in IRA and SRA. The gene expression ratios of IRA to SRA were determined for each group and compared between groups.
 
Contributor(s) Nyara M, Rush C, Karan M, Golledge J
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Submission date Feb 11, 2007
Last update date Mar 25, 2013
Contact name Jonathan Golledge
E-mail(s) jonathan.golledge@jcu.edu.au
Phone +67 7 47814730
Fax +61 7 4781 6986
URL http://www.jcu.edu.au/school/medicine/VBU.htm
Organization name James Cook University
Department School of Medicine
Lab Vascular Biology Unit
Street address School of Medicine
City Townsville
State/province Queensland
ZIP/Postal code 4811
Country Australia
 
Platforms (1)
GPL2897 GE Healthcare/Amersham Biosciences CodeLinkā„¢ Mouse Whole Genome Bioarray
Samples (10)
GSM158696 IRA_1
GSM159307 IRA_8
GSM159308 IRA_12
Relations
BioProject PRJNA99243

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