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| Status |
Public on Sep 01, 2015 |
| Title |
Cardiac adiposity is regulated by Klf4 and c-Myc |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we examined if KLF4 and c-MYC (KM)-transduced murine cardiac mesenchymal progenitors (CMPs) played a role in the differentiation into adipocytes in the absence of adipogenic stimulation cocktails. These progenitors exhibited increased expression of adipogenic-related genes, such as C/EBPα, PPARγ, and Fabp4, activation of the PPAR signaling pathway, and formation of cytoplasmic lipid droplets within 10 days. Moreover, these KM genes sharply increased following a reperfusion insult, resulting in increased ectopic fat formation. Thus, understanding CMP adipogenesis will clarify the pathophysiology of ischemic reperfusion injury and myocardial infarction and may pave the way for better treatment strategies.
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| Overall design |
Adult mouse cardiac mesenchymal progenitor cells were treated with OSKM for 0, 4, 6, or 8 days.
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| Contributor(s) |
Kami D, Gojo S |
| Citation(s) |
27077806 |
| Submission date |
Jun 21, 2015 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Satoshi Gojo |
| E-mail(s) |
gojos@koto.kpu-m.ac.jp
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| Phone |
+81-75-251-5511
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| Organization name |
Kyoto Prefectural University of Medicine
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| Street address |
465 Kajii-cho, Kamigyo-ku
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| City |
Kyoto |
| ZIP/Postal code |
602-8566 |
| Country |
Japan |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (4)
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| GSM1716941 |
Adult mouse cardiac mesenchymal progenitor without any treatment |
| GSM1716942 |
Adult mouse cardiac mesenchymal progenitor with OSKM at D4 |
| GSM1716943 |
Adult mouse cardiac mesenchymal progenitor with OSKM at D6 |
| GSM1716944 |
Adult mouse cardiac mesenchymal progenitor with OSKM at D8 |
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| Relations |
| BioProject |
PRJNA287614 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE70088_RAW.tar |
47.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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