|
| Status |
Public on Feb 15, 2007 |
| Title |
Expression data from Rat lungs |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
We sought to confirm the genetic influence in the development of Ventilation-Associated Lung Injury (VALI) and, in the process, identify potential candidate genes involved in the disease by integrating differential gene expression profiling on rat lungs to a traditional strain survey analysis of the parental rat strains, VALI-sensitive Brown Norway rats versus VALI-resistant Dahl Salt Sensitive rats, comparing control (under room air ventilation) versus under high tidal volume (HTV) ventilation.
We used microarrays to detail the global programme of gene expression underlying VALI susceptibility and identified distinct classes of up-regulated and down-regulated genes during this process.
Keywords: strain-condition analysis
|
| |
|
| Overall design |
Rat lungs (Right lungs) from both sets of parents under the two conditions (control vs. HTV ventilation) were isolated for RNA extraction and hybridization on Affymetrix microarrays.
|
| |
|
| Contributor(s) |
Stephanie N, Liliana M, Ankit D |
| Citation(s) |
17468131 |
| Submission date |
Feb 15, 2007 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Ankit A Desai |
| E-mail(s) |
adesai1@gmail.com
|
| Phone |
312-523-7931
|
| Fax |
773-834-2687
|
| Organization name |
The University of Chicago
|
| Department |
Medicine
|
| Lab |
Joe G.N. Garcia Lab / Center for Integrative Science
|
| Street address |
929 East 57th Street, Room W403R
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
|
| Samples (12)
|
| GSM162914 |
Dahl Salt Sensitive Rat Lung- Control_A72 |
| GSM162915 |
Dahl Salt Sensitive Rat Lung- Control_A73 |
| GSM162916 |
Dahl Salt Sensitive Rat Lung- Control_A81 |
| GSM162917 |
Brown Norway Rat Lung- Control_B30 |
| GSM162918 |
Brown Norway Rat Lung- Control_B31 |
| GSM162919 |
Brown Norway Rat Lung- Control_B32 |
| GSM162920 |
Dahl Salt Sensitive Rat Lung- HTV Ventilation_A69 |
| GSM162921 |
Dahl Salt Sensitive Rat Lung- HTV Ventilation_A70 |
| GSM162922 |
Dahl Salt Sensitive Rat Lung- HTV Ventilation_A82 |
| GSM162923 |
Brown Norway Rat Lung- HTV Ventilated_B36 |
| GSM162924 |
Brown Norway Rat Lung- HTV Ventilated_B37 |
| GSM162925 |
Brown Norway Rat Lung- HTV Ventilated_B40 |
|
| Relations |
| BioProject |
PRJNA98503 |
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