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Series GSE70852 Query DataSets for GSE70852
Status Public on Jul 12, 2016
Title Dorsal root ganglia (DRG) and Sciatic nerve (SCN) in female BTBR ob/ob mice - diabetic peripheral neuropathy
Organism Mus musculus
Experiment type Expression profiling by array
Summary Female mouse models of diabetic peripheral neuropathy (DPN) have not yet been identified. Our aim is firstly to demonstrate that female BTBR ob/ob mice display robust DPN and secondly, to perform relevant comparisons with non-diabetic and gender-matched controls. Lastly, microarray technology was employed to identify dysregulated genes and pathways in the SCN and DRG of female BTBR mice. Dorsal root ganglia (DRG) and sciatic nerve (SCN) were removed from female mice, RNA isolated and processed for gene expression profiling to identify differentially expressed genes using Affymetrix GeneChip Mouse Genome 430 2.0 Arrays.
Overall design Total RNA were extracted from DRG and SCN of 26 week old ob/+ and ob/ob mice (n=5 in each group) and hybridized on Affymetrix microarray.
Contributor(s) Hur J, Feldman EL
Citation(s) 25447227, 26525588
Submission date Jul 13, 2015
Last update date Oct 09, 2019
Contact name Junguk Hur
Organization name University of North Dakota
Department Biomedical Sciences
Street address 1301 N. Columbia Rd. Stop 9037
City Grand Forks
State/province ND
ZIP/Postal code 58202-9037
Country USA
Platforms (1)
GPL16368 [Mouse4302_Mm_ENTREZG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 16]
Samples (20)
GSM1820489 SCN_ob/+_1
GSM1820490 SCN_ob/+_ 2
GSM1820491 SCN_ob/+_ 3
BioProject PRJNA289686

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE70852_RAW.tar 141.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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