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| Status |
Public on Sep 18, 2015 |
| Title |
Complexity and Specificity of the Neutrophil Transcriptome in Diverse Inflammatory States |
| Platform organisms |
Homo sapiens; synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct human disease phenotypes and found that, at the gene, gene isoform, and miRNA level, neutrophils exhibit considerable specificity in their transcriptomes. These findings were particularly striking for isoform usage. Thus, even cells whose responses are considered non-specific show tailoring of their transcriptional repertoire toward specific physiologic or pathologic contexts. These findings have important implications for our understanding of the link between gene expression and disease phenotypes.
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| Overall design |
Total RNA was extracted from isolated neutrophils from patients with JIA, from patients with cystic fibrosis and from healthy controls.
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| Contributor(s) |
Jiang K, Hu Z, Frank MB, Chen Y, Jarvis JN |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 16, 2015 |
| Last update date |
May 02, 2017 |
| Contact name |
kaiyu Jiang |
| Organization name |
University at Buffalo
|
| Department |
Pediatrics
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| Street address |
875 Ellicott Street
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| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14203 |
| Country |
USA |
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| Platforms (2) |
| GPL5188 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
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| Samples (179)
|
| GSM1825262 |
Neutrophils, Patient, JIA, Biological replicate 1 |
| GSM1825263 |
Neutrophils, Patient, JIA, Biological replicate 2 |
| GSM1825264 |
Neutrophils, Patient, JIA, Biological replicate 3 |
| GSM1825265 |
Neutrophils, Patient, JIA, Biological replicate 4 |
| GSM1825266 |
Neutrophils, Patient, JIA, Biological replicate 5 |
| GSM1825267 |
Neutrophils, Patient, JIA, Biological replicate 6 |
| GSM1825268 |
Neutrophils, Patient, JIA, Biological replicate 7 |
| GSM1825269 |
Neutrophils, Patient, JIA, Biological replicate 8 |
| GSM1825270 |
Neutrophils, Patient, JIA, Biological replicate 9 |
| GSM1825271 |
Neutrophils, Patient, JIA, Biological replicate 10 |
| GSM1825272 |
Neutrophils, Patient, JIA, Biological replicate 11 |
| GSM1825273 |
Neutrophils, Patient, JIA, Biological replicate 12 |
| GSM1825274 |
Neutrophils, Patient, JIA, Biological replicate 13 |
| GSM1825275 |
Neutrophils, Patient, JIA, Biological replicate 14 |
| GSM1825276 |
Neutrophils, Patient, JIA, Biological replicate 15 |
| GSM1825277 |
Neutrophils, Patient, JIA, Biological replicate 16 |
| GSM1825278 |
Neutrophils, Patient, JIA, Biological replicate 17 |
| GSM1825279 |
Neutrophils, Patient, JIA, Biological replicate 18 |
| GSM1825280 |
Neutrophils, Patient, JIA, Biological replicate 19 |
| GSM1825281 |
Neutrophils, Patient, JIA, Biological replicate 20 |
| GSM1825282 |
Neutrophils, Patient, JIA, Biological replicate 21 |
| GSM1825283 |
Neutrophils, Patient, JIA, Biological replicate 22 |
| GSM1825284 |
Neutrophils, Patient, JIA, Biological replicate 23 |
| GSM1825285 |
Neutrophils, Patient, JIA, Biological replicate 24 |
| GSM1825286 |
Neutrophils, Patient, JIA, Biological replicate 25 |
| GSM1825287 |
Neutrophils, Patient, JIA, Biological replicate 26 |
| GSM1825288 |
Neutrophils, Patient, JIA, Biological replicate 27 |
| GSM1825289 |
Neutrophils, Patient, JIA, Biological replicate 28 |
| GSM1825290 |
Neutrophils, Patient, JIA, Biological replicate 29 |
| GSM1825291 |
Neutrophils, Patient, JIA, Biological replicate 30 |
| GSM1825292 |
Neutrophils, Patient, JIA, Biological replicate 31 |
| GSM1825293 |
Neutrophils, Patient, JIA, Biological replicate 32 |
| GSM1825294 |
Neutrophils, Patient, JIA, Biological replicate 33 |
| GSM1825295 |
Neutrophils, Patient, JIA, Biological replicate 34 |
| GSM1825296 |
Neutrophils, Patient, JIA, Biological replicate 35 |
| GSM1825297 |
Neutrophils, Cystic Fibrosis, Biological replicate 1 |
| GSM1825298 |
Neutrophils, Cystic Fibrosis, Biological replicate 2 |
| GSM1825299 |
Neutrophils, Cystic Fibrosis, Biological replicate 3 |
| GSM1825300 |
Neutrophils, Cystic Fibrosis, Biological replicate 4 |
| GSM1825301 |
Neutrophils, Cystic Fibrosis, Biological replicate 5 |
| GSM1825302 |
Neutrophils, Cystic Fibrosis, Biological replicate 6 |
| GSM1825303 |
Neutrophils, Cystic Fibrosis, Biological replicate 7 |
| GSM1825304 |
Neutrophils, Cystic Fibrosis, Biological replicate 8 |
| GSM1825305 |
Neutrophils, Cystic Fibrosis, Biological replicate 9 |
| GSM1825306 |
Neutrophils, Cystic Fibrosis, Biological replicate 10 |
| GSM1825307 |
Neutrophils, Cystic Fibrosis, Biological replicate 11 |
| GSM1825308 |
Neutrophils, Cystic Fibrosis, Biological replicate 12 |
| GSM1825309 |
Neutrophils, Cystic Fibrosis, Biological replicate 13 |
| GSM1825310 |
Neutrophils, Cystic Fibrosis, Biological replicate 14 |
| GSM1825311 |
Neutrophils, Cystic Fibrosis, Biological replicate 15 |
| GSM1825312 |
Neutrophils, Healthy control, Biological replicate 1 |
| GSM1825313 |
Neutrophils, Healthy control, Biological replicate 2 |
| GSM1825314 |
Neutrophils, Healthy control, Biological replicate 3 |
| GSM1825315 |
Neutrophils, Healthy control, Biological replicate 4 |
| GSM1825316 |
Neutrophils, Healthy control, Biological replicate 5 |
| GSM1825317 |
Neutrophils, Healthy control, Biological replicate 6 |
| GSM1825318 |
Neutrophils, Healthy control, Biological replicate 7 |
| GSM1825319 |
Neutrophils, Healthy control, Biological replicate 8 |
| GSM1825320 |
Neutrophils, Healthy control, Biological replicate 9 |
| GSM1825321 |
Neutrophils, Healthy control, Biological replicate 10 |
| GSM1825322 |
Neutrophils, Healthy control, Biological replicate 11 |
| GSM1825323 |
Neutrophils, Healthy control, Biological replicate 12 |
| GSM1825324 |
Neutrophils, Healthy control, Biological replicate 13 |
| GSM1825325 |
Neutrophils, Healthy control, Biological replicate 14 |
| GSM1825326 |
Neutrophils, Healthy control, Biological replicate 15 |
| GSM1825327 |
Neutrophils, Healthy control, Biological replicate 16 |
| GSM1825328 |
Neutrophils, Healthy control, Biological replicate 17 |
| GSM1825329 |
Neutrophils, Healthy control, Biological replicate 18 |
| GSM1825330 |
Neutrophils, Healthy control, Biological replicate 19 |
| GSM1825331 |
Neutrophils, Healthy control, Biological replicate 20 |
| GSM1825332 |
Neutrophils, Healthy control, Biological replicate 21 |
| GSM1825333 |
Neutrophils, Healthy control, Biological replicate 22 |
| GSM1825334 |
Neutrophils, Healthy control, Biological replicate 23 |
| GSM1825335 |
Neutrophils, Healthy control, Biological replicate 24 |
| GSM1825336 |
Neutrophils, Healthy control, Biological replicate 25 |
| GSM1825337 |
Neutrophils, Healthy control, Biological replicate 26 |
| GSM1825338 |
Neutrophils, Healthy control, Biological replicate 27 |
| GSM1825339 |
Neutrophils, Healthy control, Biological replicate 28 |
| GSM1825340 |
Neutrophils, Healthy control, Biological replicate 29 |
| GSM1825341 |
Neutrophils, Healthy control, Biological replicate 30 |
| GSM1825342 |
Neutrophils, Healthy control, Biological replicate 31 |
| GSM1825343 |
Neutrophils, Healthy control, Biological replicate 32 |
| GSM1825344 |
Neutrophils, Healthy control, Biological replicate 33 |
| GSM1825345 |
Neutrophils, Healthy control, Biological replicate 34 |
| GSM1825346 |
Neutrophils, Healthy control, Biological replicate 35 |
| GSM1825347 |
Neutrophils, Healthy control, Biological replicate 36 |
| GSM1825348 |
Neutrophils, Healthy control, Biological replicate 37 |
| GSM1825349 |
Neutrophils, Healthy control, Biological replicate 38 |
| GSM1825350 |
Neutrophils, Healthy control, Biological replicate 39 |
| GSM1825351 |
Neutrophils, Healthy control, Biological replicate 40 |
| GSM1825352 |
Neutrophils, Healthy control, Biological replicate 41 |
| GSM1825353 |
Neutrophils, Healthy control, Biological replicate 42 |
| GSM1825354 |
Neutrophils, Healthy control, Biological replicate 43 |
| GSM1825355 |
Neutrophils, Patient, JIA, Biological replicate 1 |
| GSM1825356 |
Neutrophils, Patient, JIA, Biological replicate 2 |
| GSM1825357 |
Neutrophils, Patient, JIA, Biological replicate 3 |
| GSM1825358 |
Neutrophils, Patient, JIA, Biological replicate 4 |
| GSM1825359 |
Neutrophils, Patient, JIA, Biological replicate 5 |
| GSM1825360 |
Neutrophils, Patient, JIA, Biological replicate 6 |
| GSM1825361 |
Neutrophils, Patient, JIA, Biological replicate 7 |
| GSM1825362 |
Neutrophils, Patient, JIA, Biological replicate 8 |
| GSM1825363 |
Neutrophils, Patient, JIA, Biological replicate 9 |
| GSM1825364 |
Neutrophils, Patient, JIA, Biological replicate 10 |
| GSM1825365 |
Neutrophils, Patient, JIA, Biological replicate 11 |
| GSM1825366 |
Neutrophils, Patient, JIA, Biological replicate 12 |
| GSM1825367 |
Neutrophils, Patient, JIA, Biological replicate 13 |
| GSM1825368 |
Neutrophils, Patient, JIA, Biological replicate 14 |
| GSM1825369 |
Neutrophils, Patient, JIA, Biological replicate 15 |
| GSM1825370 |
Neutrophils, Patient, JIA, Biological replicate 16 |
| GSM1825371 |
Neutrophils, Patient, JIA, Biological replicate 17 |
| GSM1825372 |
Neutrophils, Patient, JIA, Biological replicate 18 |
| GSM1825373 |
Neutrophils, Patient, JIA, Biological replicate 19 |
| GSM1825374 |
Neutrophils, Patient, JIA, Biological replicate 20 |
| GSM1825375 |
Neutrophils, Patient, JIA, Biological replicate 21 |
| GSM1825376 |
Neutrophils, Patient, JIA, Biological replicate 22 |
| GSM1825377 |
Neutrophils, Patient, JIA, Biological replicate 23 |
| GSM1825378 |
Neutrophils, Patient, JIA, Biological replicate 24 |
| GSM1825379 |
Neutrophils, Patient, JIA, Biological replicate 25 |
| GSM1825380 |
Neutrophils, Patient, JIA, Biological replicate 26 |
| GSM1825381 |
Neutrophils, Patient, JIA, Biological replicate 27 |
| GSM1825382 |
Neutrophils, Patient, JIA, Biological replicate 28 |
| GSM1825383 |
Neutrophils, Patient, JIA, Biological replicate 29 |
| GSM1825384 |
Neutrophils, Patient, JIA, Biological replicate 30 |
| GSM1825385 |
Neutrophils, Patient, JIA, Biological replicate 31 |
| GSM1825386 |
Neutrophils, Patient, JIA, Biological replicate 32 |
| GSM1825387 |
Neutrophils, Patient, JIA, Biological replicate 33 |
| GSM1825388 |
Neutrophils, Patient, JIA, Biological replicate 34 |
| GSM1825389 |
Neutrophils, Patient, JIA, Biological replicate 35 |
| GSM1825390 |
Neutrophils, Patient, JIA, Biological replicate 36 |
| GSM1825391 |
Neutrophils, Patient, JIA, Biological replicate 37 |
| GSM1825392 |
Neutrophils, Patient, JIA, Biological replicate 38 |
| GSM1825393 |
Neutrophils, Cystic Fibrosis, Biological replicate 1 |
| GSM1825394 |
Neutrophils, Cystic Fibrosis, Biological replicate 2 |
| GSM1825395 |
Neutrophils, Cystic Fibrosis, Biological replicate 3 |
| GSM1825396 |
Neutrophils, Cystic Fibrosis, Biological replicate 4 |
| GSM1825397 |
Neutrophils, Cystic Fibrosis, Biological replicate 5 |
| GSM1825398 |
Neutrophils, Cystic Fibrosis, Biological replicate 6 |
| GSM1825399 |
Neutrophils, Cystic Fibrosis, Biological replicate 7 |
| GSM1825400 |
Neutrophils, Cystic Fibrosis, Biological replicate 8 |
| GSM1825401 |
Neutrophils, Healthy control, Biological replicate 1 |
| GSM1825402 |
Neutrophils, Healthy control, Biological replicate 2 |
| GSM1825403 |
Neutrophils, Healthy control, Biological replicate 3 |
| GSM1825404 |
Neutrophils, Healthy control, Biological replicate 4 |
| GSM1825405 |
Neutrophils, Healthy control, Biological replicate 5 |
| GSM1825406 |
Neutrophils, Healthy control, Biological replicate 6 |
| GSM1825407 |
Neutrophils, Healthy control, Biological replicate 7 |
| GSM1825408 |
Neutrophils, Healthy control, Biological replicate 8 |
| GSM1825409 |
Neutrophils, Healthy control, Biological replicate 9 |
| GSM1825410 |
Neutrophils, Healthy control, Biological replicate 10 |
| GSM1825411 |
Neutrophils, Healthy control, Biological replicate 11 |
| GSM1825412 |
Neutrophils, Healthy control, Biological replicate 12 |
| GSM1825413 |
Neutrophils, Healthy control, Biological replicate 13 |
| GSM1825414 |
Neutrophils, Healthy control, Biological replicate 14 |
| GSM1825415 |
Neutrophils, Healthy control, Biological replicate 15 |
| GSM1825416 |
Neutrophils, Healthy control, Biological replicate 16 |
| GSM1825417 |
Neutrophils, Healthy control, Biological replicate 17 |
| GSM1825418 |
Neutrophils, Healthy control, Biological replicate 18 |
| GSM1825419 |
Neutrophils, Healthy control, Biological replicate 19 |
| GSM1825420 |
Neutrophils, Healthy control, Biological replicate 20 |
| GSM1825421 |
Neutrophils, Healthy control, Biological replicate 21 |
| GSM1825422 |
Neutrophils, Healthy control, Biological replicate 22 |
| GSM1825423 |
Neutrophils, Healthy control, Biological replicate 23 |
| GSM1825424 |
Neutrophils, Healthy control, Biological replicate 24 |
| GSM1825425 |
Neutrophils, Healthy control, Biological replicate 25 |
| GSM1825426 |
Neutrophils, Healthy control, Biological replicate 26 |
| GSM1825427 |
Neutrophils, Healthy control, Biological replicate 27 |
| GSM1825428 |
Neutrophils, Healthy control, Biological replicate 28 |
| GSM1825429 |
Neutrophils, Healthy control, Biological replicate 29 |
| GSM1825430 |
Neutrophils, Healthy control, Biological replicate 30 |
| GSM1825431 |
Neutrophils, Healthy control, Biological replicate 31 |
| GSM1825432 |
Neutrophils, Healthy control, Biological replicate 32 |
| GSM1825433 |
Neutrophils, Healthy control, Biological replicate 33 |
| GSM1825434 |
Neutrophils, Healthy control, Biological replicate 34 |
| GSM1825435 |
Neutrophils, Healthy control, Biological replicate 35 |
| GSM1825436 |
Neutrophils, Healthy control, Biological replicate 36 |
| GSM1825437 |
Neutrophils, Healthy control, Biological replicate 37 |
| GSM1825438 |
Neutrophils, Healthy control, Biological replicate 38 |
| GSM1825439 |
Neutrophils, Healthy control, Biological replicate 39 |
| GSM1825440 |
Neutrophils, Healthy control, Biological replicate 40 |
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| Relations |
| BioProject |
PRJNA290118 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE71010_RAW.tar |
2.0 Gb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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