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| Status |
Public on Sep 15, 2015 |
| Title |
RNA-sequencing of cells derived from the site of inflammation of Juvenile Idiopathic Arthritis patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Through RNA sequencing of CD4+ Tmemory/effector cells derived from the synovium of JIA patients and healthy controls, we analyzed the JIA gene expression signature. Treatment of autoinflammatory site-derived patient T cells with the BET-inhibitor JQ1 inhibited immune-related super-enhancers and preferentially reduced disease-associated gene expression, including cytokine-related processes.
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| |
|
| Overall design |
RNA-sequencing of CD4+ memory/effector T cells derived from Healthy Controls (HC) and JIA patients upon JQ1 treatment.
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| |
|
| Contributor(s) |
van Loosdregt J, Peeters JG, Vervoort SJ |
| Citation(s) |
26387944 |
| Submission date |
Jul 31, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Janneke Peeters |
| E-mail(s) |
j.g.c.peeters-7@umcutrecht.nl
|
| Organization name |
UMC Utrecht
|
| Street address |
Heidelberglaan 100
|
| City |
Utrecht |
| ZIP/Postal code |
3584CX |
| Country |
Netherlands |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE71597 |
Epigenetic profiling and RNA-sequencing of Juvenile Idiopathic Arthritits (JIA) patients |
|
| Relations |
| BioProject |
PRJNA291597 |
| SRA |
SRP061881 |
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