|
| Status |
Public on Sep 15, 2015 |
| Title |
Epigenetic profiling of Juvenile Idiopathic Arthritits (JIA) patients |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
With H3K27ac chromatin immunoprecipitation we identified a disease-specific, inflammation-associated, (super-)enhancer signature in JIA patient synovial fluid-derived CD4+ memory/effector T cells. This signature consists of unique pathogenesis-associated epigenetic changes which extend beyond general T cell activation-induced alterations, indicating that disease-specific (super-)enhancers contribute to JIA pathogenesis. In addition, our analysis shows that there is a profound enrichment of JIA-related SNPs in (super-)enhancers in JIA patients compared to controls, illustrating the importance of these non-coding regions for disease pathogenesis.
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| |
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| Overall design |
H3K27ac ChIP-sequencing of CD4+ memory/effector T cells derived from peripheral blood (PB) from healthy controls (HC) and PB or synovial fluid (SF) from JIA patients.
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| |
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| Contributor(s) |
. van Loosdregt J, Peeters JG, Vervoort SJ |
| Citation(s) |
26387944 |
| Submission date |
Jul 31, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Janneke Peeters |
| E-mail(s) |
j.g.c.peeters-7@umcutrecht.nl
|
| Organization name |
UMC Utrecht
|
| Street address |
Heidelberglaan 100
|
| City |
Utrecht |
| ZIP/Postal code |
3584CX |
| Country |
Netherlands |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE71597 |
Epigenetic profiling and RNA-sequencing of Juvenile Idiopathic Arthritits (JIA) patients |
|
| Relations |
| BioProject |
PRJNA291598 |
| SRA |
SRP061882 |
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