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| Status |
Public on Apr 29, 2016 |
| Title |
Increased antigenicity of NURF-depleted tumors enhances CD8 T cell-mediated antitumor immunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Depleting the NURF chromatin remodeling complex results in enhanced antitumor immunity using mouse tumor models syngenic to two strain backgrounds.
Selective depletion of immune cells from tumor-bearing mice discovers that both CD8+ and CD4+ cells are necessary for enhanced antitumor immunity to NURF-depleted cells. Our results suggest that NURF-depleted cells have significant differences in antigenicity compared to control cells.
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| Overall design |
Cloning, functional and molecular assays of CD8 T cells were performed to identify clones with enhanced activity to NURF-depleted tumor cells in NSG mice compared to control tumors.
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| |
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| Contributor(s) |
Landry J, Dumur CI, Mayes K |
| Citation(s) |
27651309 |
| Submission date |
Aug 07, 2015 |
| Last update date |
May 04, 2018 |
| Contact name |
Catherine Dumur |
| Organization name |
Sonic Healthcare USA
|
| Department |
Anatomic Pathology
|
| Lab |
Bernhardt
|
| Street address |
5008 Mustang Rd
|
| City |
Jacksonville |
| State/province |
FL |
| ZIP/Postal code |
32216 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA292333 |
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