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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 01, 2015 |
| Title |
Identification of a Highly Immunogenic Mouse Breast Cancer Sub Cell Line, 4T1-S |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Recently, cancer immunotherapy has been paid much attention because of its improved efficacy and low frequency of adverse effects. A mouse breast cancer cell line, 4T1, has been known as poorly immunogeneic and highly metastatic cell line. In this study, we have identified a sub cell line of 4T1, designated as 4T1-Sapporo (4T1-S), which could induce a strong immune response against the same line. When 4T1-S was subcutaneously injected, striking enlargement of draining lymph nodes and increase of activated T cells were observed. The strong immune responses could not be observed when 4T1-S was injected to nude mice, indicating that this phenomenon is mediated by T cell response. Identification of 4T1-S characteristics may help to improve immunotherapy against breast cancer.
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| Overall design |
4T1-A1, 4T1-A2, 4T1-S1, 4T1-S2
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| Contributor(s) |
Abe H, Seino K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 11, 2015 |
| Last update date |
May 10, 2018 |
| Contact name |
Hirotake ABE |
| E-mail(s) |
hirotake620@igm.hokudai.ac.jp
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| Phone |
+81117065532
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| Organization name |
Hokkaido University
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| Department |
Institute for Genetic Medicine
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| Lab |
Immunobiology
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| Street address |
Kita15-Nishi7, Kitaku
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| City |
Sapporo |
| State/province |
Japan/Hokkaido |
| ZIP/Postal code |
060-0815 |
| Country |
Japan |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA292490 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE71926_RAW.tar |
27.1 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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