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| Status |
Public on Aug 18, 2015 |
| Title |
Expression data from hyperoxaluric rats |
| Platform organism |
synthetic construct |
| Sample organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Calcium oxalate stones account for over 80% of urinary stones, while the molecular mechanism of its formation is still not completely elucidated. The incidence of hyperoxaluria in calcium oxalate stone formation ranks only second to hypercalciuria. It plays an important role in the pathophysiological process of stone formation. We analyzed miRNA expression profiles between experimental hyperoxaluric rats and normal rats in order to find out the target genes and signaling pathways in the pathogenesis of hyperoxaluria.
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| Overall design |
We feed ethylene glycol (EG) and ammonium chloride (AC) to male experimental hyperoxaluric rats (T group) and age-matched male rats selected as control group (C group). The oxalate concentration in 24-hour urine of each experimental rat was measured and the three highest were selected for microarray test. MicroRNA microarray was applied to evaluate the expression difference between the two groups and screen miRNA that were above 2- or below 0.5-fold change.
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| Contributor(s) |
Jiang H, Liu Z |
| Citation missing |
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| Submission date |
Aug 18, 2015 |
| Last update date |
May 02, 2017 |
| Contact name |
Jiang Hongyang |
| E-mail(s) |
jiang.hongyang@163.com
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| Organization name |
Tongji Hospital, Huazhong University of Science and Technology
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| Street address |
No. 1095 Jie Fang Avenue
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| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430000 |
| Country |
China |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA293162 |
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