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| Status |
Public on Jun 04, 2012 |
| Title |
Leukemic hematopoietic stem cell FLA2 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Sca1+Lineage-cKit+ fetal liver (FL) and bone marrow (BM) cells were sorted and infected with Hoxa9+Meis retroviral particles, which provided fully leukemic complement to hematopoietic cells. These cells were injected into mice and leukemia onset was monitored in vivo. Leukemic stem cell (L-HSC) frequencies of these primary leukemias were evaluated using limiting dilution stem cell transfer in secondary recipients. The L-HSC frequency is near absolute for the FLA2 leukemia (around 1 L-HSC per 1.4 total leukemic bone marrow cells), whereas the other leukemias (FLB1, FLB2 and BM-derived leukemias) generated within the same experiment have a wide range of L-HSC frequencies.
Keywords: other
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| Overall design |
this experiment include 6 samples and 16 replicates
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| Contributor(s) |
Sauvageau G, Faubert A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 09, 2007 |
| Last update date |
Jan 08, 2019 |
| Organization |
Ottawa Hospital Research Institute |
| Phone |
(613) 737-8899 -73255
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| Department |
Cellular and Molecular Medicine
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| Lab |
Ottawa Bioinformatics Core Facility
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| Street address |
501 Smyth Rd.
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| City |
Ottawa |
| State/province |
ON |
| ZIP/Postal code |
K1H 8L6 |
| Country |
Canada |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (16)
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| GSM174488 |
FLB1-2, chip MOE430A |
| GSM174489 |
FLB1-3, chip MOE430A |
| GSM174490 |
FLB2-1, chip MOE430A |
| GSM174491 |
FLB2-2, chip MOE430A |
| GSM174492 |
BMA1-1, chip MOE430A |
| GSM174493 |
BMA1-2, chip MOE430A |
| GSM174494 |
BMA1-3, chip MOE430A |
| GSM174495 |
BMA3-1, chip MOE430A |
| GSM174496 |
BMA3-2, chip MOE430A |
| GSM174497 |
BMA3-3, chip MOE430A |
| GSM174498 |
BMA5-1, chip MOE430A |
| GSM174499 |
BMA5-2, chip MOE430A |
| GSM174500 |
BMA5-3, chip MOE430A |
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| Relations |
| BioProject |
PRJNA97917 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE7235_RAW.tar |
145.3 Mb |
(http)(custom) |
TAR (of CEL, CHP, EXP) |
| Processed data provided as supplementary file |
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