|
| Status |
Public on Nov 01, 2015 |
| Title |
Late chick lung development |
| Organism |
Gallus gallus |
| Experiment type |
Expression profiling by array
|
| Summary |
Type IV collagen is the main component of the basement membrane which gives strength to the blood-gas barrier. In avians the formation of the blood-gas barrier happens rapidly and before hatching. We have performed a microarray expression analysis in late chick lung development and found that COL4A1 and COL4A2 were among the most significantly upregulated genes during the formation of the avian blood-gas barrier. Our study showed that type IV collagen and therefore the basement membrane play fundamental roles in coordinating alveolar morphogenesis.
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| |
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| Overall design |
Four developmental stages of chick lung maturation (E14, E15, E16, E18). Three biological replicates per time point.
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| |
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| Contributor(s) |
Loscertales M, Maalouf FI |
| Citation(s) |
27412481 |
| Submission date |
Aug 26, 2015 |
| Last update date |
Jul 18, 2019 |
| Contact name |
Maria Loscertales |
| E-mail(s) |
mloscertales@partners.org
|
| Phone |
617-7249184
|
| Organization name |
Massachusetts General Hospital
|
| Department |
Pediatric Surgery
|
| Lab |
Pediatric Surgical Research Laboratories
|
| Street address |
185 Cambridge St
|
| City |
Boston |
| State/province |
Ma |
| ZIP/Postal code |
02114 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20851 |
NimbleGen Gallus gallus gene expression array [090126_Ggal_ML_exp] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA295962 |
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