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| Status |
Public on Aug 28, 2015 |
| Title |
Interactions of PfETRAMP14.1 with PfEMP1 and EXP-2 at the parasitophorous vacuolar membrane (PVM) of human malaria parasite Plasmodium falciparum [HIGH PARASITEMIA ANALYSIS] |
| Platform organisms |
Plasmodium falciparum; Anopheles gambiae |
| Sample organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In our global differential gene expression analyses,ETRAMP14.1, an ETRAMP family member was found to be highly transcribed in vivo in severe
Malaria patients from highly endemic Indian region. This study for the first time reports the interaction of ETRAMP14.1 with PfEMP1, EXP2 and Hsp70-1.
Therefore, we propose that ETRAMP14.1 facilitate PfEMP1 to cross the PVM via transcolon machinery component EXP2.
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| Overall design |
Peripheral blood samples containing ring forms of the P.falciparum from mild and severe malaria patients were used for RNA extraction, CDNA synthesis and hybridization on Affymetrix microarrays. In vitro ring stage P.falciparum cultures were used for normalization.
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| Contributor(s) |
Kirthana MV, Ghosh SK, Kumar S, Surolia N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 27, 2015 |
| Last update date |
Aug 29, 2015 |
| Contact name |
Sanjeev Kumar |
| E-mail(s) |
sanjeev@biocosls.in
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| Organization name |
BioCOS Life Sciences Pvt Ltd
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| Department |
R&D
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| Lab |
R&D Bioinformatics
|
| Street address |
526/A,19th Main,3-sect,Ganesh Complex (2nd Floor) HSR Layout
|
| City |
Bangalore |
| State/province |
Karnataka |
| ZIP/Postal code |
560102 |
| Country |
India |
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| Platforms (1) |
| GPL1321 |
[Plasmodium_Anopheles] Affymetrix Plasmodium/Anopheles Genome Array |
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| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE72448 |
Interactions of PfETRAMP14.1 with PfEMP1 and EXP-2 at the parasitophorous vacuolar membrane (PVM) of human malaria parasite Plasmodium falciparum |
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| Relations |
| BioProject |
PRJNA294080 |
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