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| Status |
Public on Sep 30, 2015 |
| Title |
Islet microRNA changes in the rat pancreatic islets during aging |
| Organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
comparison of microRNA expression in the islets of 3- and 12-months old male Wistar rats
Aging is a risk factor for a majority of metabolic diseases including type 2 diabetes. During aging pancreatic beta-cell function decreases leading to impaired insulin secretion and proliferation and to an increase in apoptosis. Impairment of pancreatic beta cell functions and survival has been linked to gene expression changes. The aim of our study was to obtain a global expression profile of microRNAs and mRNAs of pancreatic islets of 3 and 12 month old male Wistar rats in order to identify the changes occurring during aging.
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| Overall design |
Total RNA isolated from the pancreatic islets of three 3-month old and four 12-month old rats was analyzed by microarray to determine the microRNA profile
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| Contributor(s) |
Tugay K, Regazzi R |
| Citation(s) |
26474776 |
| Submission date |
Aug 27, 2015 |
| Last update date |
Jun 20, 2019 |
| Contact name |
Romano Regazzi |
| E-mail(s) |
romano.regazzi@unil.ch
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| Organization name |
University of Lausanne
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| Department |
DNF
|
| Street address |
Rue du Bugnon 9
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| City |
Lausanne |
| ZIP/Postal code |
1005 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL14860 |
Agilent-031189 Unrestricted_Rat_miRNA_v16.0_Microarray (miRNA ID version) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE72466 |
microRNA and mRNA expression in pancreatic islets of 3 and 12 month old male Wistar rats |
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| Relations |
| BioProject |
PRJNA294101 |
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