|
| Status |
Public on Oct 30, 2015 |
| Title |
Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The causative role of activated Hedgehog signaling in liver fibrosis was investigated in vivo.
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| |
|
| Overall design |
Using hydrodynamics-based transfection, a transgenic mouse model has been developed that expresses Sonic Hedgehog (SHH), a ligand for Hedgehog signaling, in the liver. Levels of hepatic fibrosis and fibrosis-related gene expression were assessed in the model.
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| |
|
| Contributor(s) |
Chung SI, Ro SW, Eun JW, Nam SW |
| Citation(s) |
26471504 |
| Submission date |
Sep 07, 2015 |
| Last update date |
Oct 18, 2022 |
| Contact name |
Jung Woo Eun |
| E-mail(s) |
jetaimebin@catholic.ac.kr
|
| Organization name |
Ajou University of Korea
|
| Street address |
Department of Gastroenterology
|
| City |
Suwon, Korea |
| State/province |
Korea |
| ZIP/Postal code |
16499 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA294966 |
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