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| Status |
Public on Nov 01, 2015 |
| Title |
Next Generation Sequencing Methylation Profiling in Skeletal Muscle from Lean and Obese Subjects [Microarray expression] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Obesity is a metabolic disease caused by environmental, genetic, and epigenetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to identify skeletal muscle DNA methylation patterns in combination with transcriptomic changes in obesity.
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| Overall design |
Muscle biopsies were obtained basally from lean (n=10) and obese (n=10) participants in combination with euglycemic hyperinsulinemic clamps to assess insulin sensitivity. We performed microarray (SurePrint G3 Human Gene Expression 8x60K v2) analysis on RNA isolated from vastus lateralis muscle biopsies. This represents the expression profiling component only.
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| Contributor(s) |
Day SE, Coletta DK, Coletta RL |
| Citation(s) |
27437034, 28883895 |
| Submission date |
Sep 16, 2015 |
| Last update date |
Jul 10, 2019 |
| Contact name |
Samantha Elaine Day |
| E-mail(s) |
seday918@gmail.com
|
| Organization name |
Arizona State University
|
| Street address |
University Dr. and Mill Ave.
|
| City |
Tempe |
| State/province |
AZ |
| ZIP/Postal code |
85281 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE73304 |
Next Generation Sequencing Methylation Profiling in Skeletal Muscle from Lean and Obese Subjects |
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| Relations |
| BioProject |
PRJNA296052 |
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