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Series GSE7310 Query DataSets for GSE7310
Status Public on Jan 01, 2008
Title Comparison analysis of 2 week old C57BL6J lung exposed to 2 weeks of cigarette smoke compared to age-matched controls
Organism Mus musculus
Experiment type Expression profiling by array
Summary We hypothesize that gene expression in the cigarette smoke (CS) exposed neonatal lung and age-matched controls will be divergent. CS exposed lung will have divergence of immune response genes and structural genes. The lungs of (6) 2 week old neonatal mice exposed to 2 weeks of CS were compared to the lung of (4) 2 week old age-matched control mice. We utilized microarray analysis to examine transcriptional differences between smoke exposed neonatal lung and age-matched controls.
Keywords: comparative expression profiling
 
Overall design This study utilizes microarray analysis to test these hypotheses. Six sets of lungs were harvested from CS exposed mice and four sets of lungs were harvested from age-matched control mice. RNA was isolated and used for global gene expression profiling (Affymetrix Mouse 430 2.0 array). Statistically significant gene expression was determined as a minimum 6 counts of 9 pairwise comparisons, minimum 1.5-fold change, and p < 0.05. Further, Absolute | FC - FC SEM | >= 1.5.
 
Contributor(s) McGrath-Morrow S, Biswal S, Rangasamy T, Cho C
Citation(s) 17975176
Submission date Mar 19, 2007
Last update date Feb 11, 2019
Contact name Sharon McGrath-Morrow
E-mail(s) smorrow@jhmi.edu
Phone 410-614-5637
Fax 410-955-1030
Organization name Johns Hopkins
Department Pediatrics
Street address 200 N.Wolfe St.
City Baltimore
State/province MD
ZIP/Postal code 21287
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (10)
GSM176495 2 week old C57BL6 control lung 1
GSM176496 2 week old C57BL6 control lung 2
GSM176497 2 week old C57BL6 control lung 3
Relations
BioProject PRJNA97967

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Supplementary file Size Download File type/resource
GSE7310_RAW.tar 42.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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