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Series GSE7342 Query DataSets for GSE7342
Status Public on Mar 23, 2007
Title Expression data from p38 knock out versus wild type fetal liver
Organism Mus musculus
Experiment type Expression profiling by array
Summary The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses develop to term but die shortly after birth, likely due to lung dysfunction. Fetal hematopoietic cells and embryonic fibroblasts deficient in p38alpha display increased proliferation, resulting from sustained activation of the c-Jun N-terminal kinase (JNK)/c-Jun pathway. Importantly, in chemical-induced liver cancer development, mice with liver-specific deletion of p38alpha show enhanced hepatocyte proliferation and tumor development that also correlates with JNK/c-Jun upregulation. Furthermore, increased proliferation of p38alpha-deficient hepatocytes and tumor cells is suppressed by inactivation of JNK or c-Jun. These results reveal a novel mechanism whereby p38alpha negatively regulates cell proliferation through antagonizing the JNK/c-Jun pathway in multiple cell types and in liver cancer development.
We used microarrays to identifiy differental regulated genes by p38alpha in fetal liver cells
Keywords: time course
Overall design Wild type and p38 deficient fetal liver cell were used for RNA extraction and hybridization on Affymetrix microarrays.
Contributor(s) Hui L, Schweifer N, Haslinger C, Wagner EF
Citation(s) 17468757
Submission date Mar 22, 2007
Last update date Feb 11, 2019
Contact name Norbert Schweifer
Organization name Boehringer Ingelheim Austria
Street address Dr. Boehringer Gasse 5-11
City Vienna
ZIP/Postal code 1120
Country Austria
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM177031 p38alpha knock out fetal liver E13.5, biological rep1
GSM177032 p38alpha knock out fetal liver E13.5, biological rep2
GSM177033 p38alpha knock out fetal liver E13.5, biological rep3
BioProject PRJNA98027

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Supplementary file Size Download File type/resource
GSE7342_RAW.tar 40.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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