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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 06, 2015 |
| Title |
Gene expression profiling of novel glucocorticoids in RAW264.7 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate the anti-inflammation activity of novel glucocorticoids on gene expression of macrohpage cells, we use mouse macrophage RAW264.7 cells to profiling gene expression pattern of novel glucocorticoids upon the onset of inflammation response.
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| Overall design |
Pretreated cells with various glucocorticoids (Dexamethasone, VSG22, VSGC12 and Fluticasone Furoate) one hour before induction of inflammation resposne via LPS for overnight, each treatment has two replicate. 16 hours after treatment, harvest total RNA for gene profiling.
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| Contributor(s) |
Gao X, He Y, Xu E |
| Citation |
Yuanzheng He, Jingjing Shi, Wei Yi, Xin Ren, Xiang Gao, Jianshuang Li, Nanyan Wu, Kevin Weaver, Qian Xie, Sok Kean Khoo, Tao Yang, Xiaozhu Huang, Karsten Melcher & H Eric Xu. Discovery of a highly potent glucocorticoid for asthma treatment. Cell Discovery 1, 15 December, Article number: 15035 (2015) http://0-dx-doi-org.brum.beds.ac.uk/10.1038/celldisc.2015.35
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| Submission date |
Oct 05, 2015 |
| Last update date |
Jul 19, 2017 |
| Contact name |
Eric Xu |
| E-mail(s) |
Eric.Xu@vai.org
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| Phone |
6162345772
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| Organization name |
Van Andel Institute
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| Street address |
333 Bostwick Ave
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| City |
Grand Rapids |
| State/province |
MICHIGAN |
| ZIP/Postal code |
49503 |
| Country |
USA |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (10)
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| GSM1901829 |
mouse_macrophage_cell_R264.7_EtoH_rep1 |
| GSM1901830 |
mouse_macrophage_cell_R264.7_EtoH_rep2 |
| GSM1901831 |
mouse_macrophage_cell_R264.7_VSG22_rep1 |
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| Relations |
| BioProject |
PRJNA297784 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE73733_RAW.tar |
129.1 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE73733_RAW264.7fit.xlsx |
14.2 Mb |
(ftp)(http) |
XLSX |
| Processed data included within Sample table |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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